DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and DOC2A

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_024306240.1	Gene:	DOC2A / 8448	HGNCID:	2985	Length:	467	Species:	Homo sapiens

Alignment Length:	381	Identity:	116/381 - (30%)
Similarity:	158/381 - (41%)	Gaps:	98/381 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 ENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAE------------------------ 217
            |:..|.|..|......||.|.|.|.||..|.:|..::::|:
Human    74 EDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKVGTPCHPSPGPVCVQPPEGAHSSF 138

  Fly   218 ----------------------------ELPA---------------LDMGGTSDPYVKVYLLPD 239
                                        |:|.               :|..|.:|||||::|||.
Human   139 PSQACSFVLPLPPPSGLLQGPALQEGWREVPGASSPLPCPPLQGLKPMDFNGLADPYVKLHLLPG 203

  Fly   240 --KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTI 302
              |..|.:||..|.||:||:||..|:..:...|..:|.|..|:.|.|:.|.::.|||::|||..:
Human   204 ACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRL 268

  Fly   303 DLAQ------TIEEWRDLVS---------------------VEGEGGQEKLGDICFSLRYVPTAG 340
            ..:|      .:|....|.|                     .:|:|..|:.|.|..||.|.....
Human   269 KPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRR 333

  Fly   341 KLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQI 405
            .|.|.||...:|..|||.|.||||||..:..:..:..|.||.:||.||||.:||.|.:|:....:
Human   334 GLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTL 398

  Fly   406 QKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            ....|.|||.||| ||.|.. ||...||....|...:||||.|..|...:.:||||
Human   399 ATKTLEVTVWDYD-IGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	50/198 (25%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	58/136 (43%)
DOC2A	XP_024306240.1	C2A_Rabphilin_Doc2	90..280	CDD:176000	48/189 (25%)
DOC2A	XP_024306240.1	C2B_Rabphilin_Doc2	321..453	CDD:176030	55/132 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910