DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syt1 and DOC2B

DIOPT Version :10

Sequence 1:NP_523460.2 Gene:Syt1 / 33473 FlyBaseID:FBgn0004242 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_003576.2 Gene:DOC2B / 8447 HGNCID:2986 Length:412 Species:Homo sapiens


Alignment Length:338 Identity:120/338 - (35%)
Similarity:172/338 - (50%) Gaps:22/338 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 KRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPD--------MEELTENAEEGDEEDKQSEQKLGRL 196
            :|...||..:...|:.  ||.| ||.....|.        ..:..|:..:.|..:......||.|
Human    69 RRSPSDGAREDDEDVD--QLFG-AYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTL 130

  Fly   197 NFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLP--DKKKKFETKVHRKTLSPVFNE 259
            :|.|.||..:|:|..|:.:|:.|..:|..|.:|||||::|||  .|..|..||..|.||:|.:||
Human   131 DFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNE 195

  Fly   260 TFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQT------IEEWRDLVSVE 318
            |.|:..:...|.:.|||..::.|.|:|..::.|||.:|||..:....|      :|:...:...|
Human   196 TLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTE 260

  Fly   319 GEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSI 383
            .:..:|: |.|..||:|......|.|.|:...:|..||..|.||||||..:..:..:..|.||::
Human   261 DKSLEER-GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324

  Fly   384 KKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDML 447
            ||.||||.:||.|.:|:....:.|..|.|||.||| ||.|.. ||..:||....|..|:||.|.|
Human   325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYD-IGKSNDFIGGVVLGIHAKGERLKHWFDCL 388

  Fly   448 ASPRRPIAQWHTL 460
            .:..:.|.:||||
Human   389 KNKDKRIERWHTL 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt1NP_523460.2 Syt1_2_N 62..161 CDD:425364 6/20 (30%)
C2A_Synaptotagmin-1-5-6-9-10 192..316 CDD:176031 49/131 (37%)
C2B_Synaptotagmin-1 326..461 CDD:176047 57/136 (42%)
DOC2BNP_003576.2 Mediates interaction with DYNLT1. /evidence=ECO:0000269|PubMed:9804756 1..90 7/23 (30%)
Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250 1..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123 12/56 (21%)
C2A_Rabphilin_Doc2 127..250 CDD:176000 48/122 (39%)
Mediates interaction with STXBP3. /evidence=ECO:0000250 257..375 48/119 (40%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 54/132 (41%)
Blue background indicates that the domain is not in the aligned region.

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