DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and DOC2B

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_003576.2	Gene:	DOC2B / 8447	HGNCID:	2986	Length:	412	Species:	Homo sapiens

Alignment Length:	338	Identity:	120/338 - (35%)
Similarity:	172/338 - (50%)	Gaps:	22/338 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 KRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPD--------MEELTENAEEGDEEDKQSEQKLGRL 196
            :|...||..:...|:.  ||.| ||.....|.        ..:..|:..:.|..:......||.|
Human    69 RRSPSDGAREDDEDVD--QLFG-AYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTL 130

  Fly   197 NFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLP--DKKKKFETKVHRKTLSPVFNE 259
            :|.|.||..:|:|..|:.:|:.|..:|..|.:|||||::|||  .|..|..||..|.||:|.:||
Human   131 DFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNE 195

  Fly   260 TFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQT------IEEWRDLVSVE 318
            |.|:..:...|.:.|||..::.|.|:|..::.|||.:|||..:....|      :|:...:...|
Human   196 TLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTE 260

  Fly   319 GEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSI 383
            .:..:|: |.|..||:|......|.|.|:...:|..||..|.||||||..:..:..:..|.||::
Human   261 DKSLEER-GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAV 324

  Fly   384 KKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDML 447
            ||.||||.:||.|.:|:....:.|..|.|||.||| ||.|.. ||..:||....|..|:||.|.|
Human   325 KKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYD-IGKSNDFIGGVVLGIHAKGERLKHWFDCL 388

  Fly   448 ASPRRPIAQWHTL 460
            .:..:.|.:||||
Human   389 KNKDKRIERWHTL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	49/131 (37%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	57/136 (42%)
DOC2B	NP_003576.2	Mediates interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:9804756	1..90		7/23 (30%)
		Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123		12/56 (21%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	48/122 (39%)
		Mediates interaction with STXBP3. /evidence=ECO:0000250	257..375		48/119 (40%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	54/132 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910