DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and SYT15

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_024303996.1	Gene:	SYT15 / 83849	HGNCID:	17167	Length:	474	Species:	Homo sapiens

Alignment Length:	297	Identity:	105/297 - (35%)
Similarity:	161/297 - (54%)	Gaps:	12/297 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYV 232
            :.|::.:..|:..|.|..|    ..||||.|.:||:..:..|.|.:|:|:.|.|  ...|..|.|
Human   180 INPELYKFPEDKSETDFPD----GCLGRLWFSVEYEQEAERLLVGLIKAQHLQA--PSETCSPLV 238

  Fly   233 KVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKV 297
            |:|||||:::..::|..|||.:|.|:|.|.|: :.......:.|.|:::..||..||..:|:|..
Human   239 KLYLLPDERRFLQSKTKRKTSNPQFDEHFIFQ-VSSKTITQRVLKFSVYHVDRQRKHQLLGQVLF 302

  Fly   298 PLCTIDLAQTIEE--WRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGL 360
            ||....|......  ||||.:...|...| .||:.|.|.|.....:||||:|.||.|:..:..|:
Human   303 PLKNETLVGDCRRVIWRDLEAESLEPPSE-FGDLQFCLSYNDYLSRLTVVVLRAKGLRLQEDRGI 366

  Fly   361 SDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP 425
            ...:||:::|.:.|.:|.||||....::||.|||:|||:....::....|.:|||.......|:.
Human   367 VSVFVKVSLMNHNKFVKCKKTSAVLGSINPVYNETFSFKADATELDTASLSLTVVQNMEGDKSQQ 431

  Fly   426 IGRCILG-CMGT-GTELRHWSDMLASPRRPIAQWHTL 460
            :||.::| .|.| |.||.||.:||:.|:..:.:||.|
Human   432 LGRVVVGPYMYTRGRELEHWDEMLSKPKELVKRWHAL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	46/125 (37%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	52/137 (38%)
SYT15	XP_024303996.1	C2A_Synaptotagmin-15-17	202..322	CDD:176036	44/122 (36%)
SYT15	XP_024303996.1	C2B_Synaptotagmin-15	332..469	CDD:176054	52/137 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820