Protein Alignment Syt1 and Sytl2

DIOPT Version :9

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001355807.1
• Gene: Sytl2 / 83671
• MGIID: 1933366
• Length: 2153
• Species: Mus musculus
• Alignment Length: 590
• Identity: 138/590 - (23%)
• Similarity: 220/590 - (37%)
• Gaps: 193/590 - (32%)

  Fly     8 ETDAKPEAEPAPASEPAADLESVDQK-----LEETHHS--KFREV--------DRQEQEVLAEKA 57
            ||.|..|    |..|.|....||.:.     |.||...  |.|||        .|||:|...|..
Mouse  1608 ETQASQE----PGFEEAPKEMSVSRNKHSIVLLETKGKAIKTREVKLVLATPYKRQEEEQGPEAC 1668

  Fly    58 AE-------AASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGV 115
            :|       .:|.|    |:...::::|.:.|     ||:|.:|
Mouse  1669 SEYEFSDGNTSSNR----ENWRNTSSSEEEHS-----PVLKTLE--------------------- 1703

  Fly   116 VAIIILVFLVVFGIIFFCVRRFLKKRRTK-------DGKGKKGVDMKSVQLLGSA---YKEKVQP 170
                               ||..:|..:|       |...:..||....:|:.||   .|...:|
Mouse  1704 -------------------RRAARKLPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEP 1749

  Fly   171 DMEE----------LTEN-------------------AEEGDEED--------------KQSEQK 192
            |..|          |.:|                   .:|.|:.:              |:|...
Mouse  1750 DTNECIPGISTVPSLPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLRRYKKSPSS 1814

  Fly   193 L---------------------------------GRLNFKLEYDFNSNSLAVTVIQAEELPALDM 224
            |                                 |.:.|.|:|..:...|.|.|.|.::|.|.|:
Mouse  1815 LTNLSSSSGMTSLSSASGSVMSVYSGDFGNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADV 1879

  Fly   225 -GGTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRF 286
             ...||||||.||||||.|  |.:|.|.:|||:||:||...:| :.......:.|..:::..|.|
Mouse  1880 KKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IERQFLKTQKLNLSVWHRDTF 1943

  Fly   287 SKHDQIGEVKVPLCTIDLAQTIE---EWRDL------VSVEGEGGQEKLGDICFSLRYV------ 336
            .::..:|||::.|.|.|......   :|..|      |::|    .|..|::..:|:||
Mouse  1944 KRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKTAPVALE----TENRGEMKLALQYVPEPSPG 2004

  Fly   337 ---PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSF 398
               ||.|::.:.:.|..:|..:. |...:.:||..|:.:..|..::||.....|.||.:|.:..:
Mouse  2005 KKLPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVY 2068

  Fly   399 EVPF--EQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLK 461
            : .|  |.:.:.|:.:||.|:.:: |::.:|...:| .|||.......|.:.|....:|.|..:.
Mouse  2069 D-GFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIG-FGTGKSYGTEVDWMDSTSEEVALWEKMV 2130

  Fly   462 DPEET 466
            :...|
Mouse  2131 NSPNT 2135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	31/149 (21%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	47/168 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	36/145 (25%)
Sytl2	NP_001355807.1	PHD_SF	5..>41	CDD:419867
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..98
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..289
		C2A_SLP-1_2	1848..1975	CDD:176039	45/127 (35%)
		C2B_SLP_1-2-3-4	1988..2144	CDD:175987	37/152 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810