DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and syt9a

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_001336058.4	Gene:	syt9a / 798433	ZFINID:	ZDB-GENE-031002-18	Length:	547	Species:	Danio rerio

Alignment Length:	500	Identity:	183/500 - (36%)
Similarity:	259/500 - (51%)	Gaps:	92/500 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRI 65
            :.|..| |....|...|.|..:|......||..|           ||:            ::.|.
Zfish    88 LSPGTK-EGHPDPPHPPPPPLQPQPIYTEVDATL-----------DRR------------SNARS 128

  Fly    66 AQVESTTRSAT--TEAQESTTTAVPVIK---KIEHVGEVVTEVIAERT---GL------------ 110
            :.|:.||...|  :.|...:..||||.:   ||.|....:...:..:|   |:
Zfish   129 SVVKETTVPPTPVSPAVPGSPPAVPVPEAALKISHTSPDIPLEVESKTQENGVHGNTRMQRQITD 193

  Fly   111 PTWGVVAIIILVFLVVFGIIFFCVRRFLKKRR----------TKDGKGKKGVDMKSVQLLGSAYK 165
            |:                  ..|||:...:|:          |:..:......|...||....||
Zfish   194 PS------------------STCVRQSSIRRQMNQSNPDFTVTQFQRQDSLTGMSLGQLKPELYK 240

  Fly   166 EKVQPDMEELTENAEEGDEEDKQSEQ--KLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTS 228
            ::             ..|.||.:|.:  ..|||:|.|:||.:...|.|.:.:|::|||.|..|||
Zfish   241 QR-------------SLDGEDSRSSRVGSCGRLHFILKYDCDLEQLIVKIHRAQDLPAKDFSGTS 292

  Fly   229 DPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIG 293
            |||||:|||||:|.|.:||||||||:|||:|.|.| .:.|||...:.|.|:::||||||:||.||
Zfish   293 DPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLF-PVAYADLPTRKLHFSVYDFDRFSRHDIIG 356

  Fly   294 EVKVP--LCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMD 356
            :|.|.  |..:|..:..:..||:..|..:  ...|||:.|||.|:||||:||:.:::|:|||.||
Zfish   357 QVVVDNFLDLVDFPRETKLCRDIQYVSSD--NVDLGDLMFSLCYLPTAGRLTITMIKARNLKAMD 419

  Fly   357 VGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIG 421
            :.|.||||||:::|.:|:||||:|||.|:.||||.|||:..|:||.|.|.:|.|:|.|:||||:|
Zfish   420 ITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQISLLVAVMDYDRVG 484

  Fly   422 TSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEET 466
            .:|.||.|.:|....|....||::||..||:|||.||.|.:...|
Zfish   485 HNEVIGVCRVGNDAEGLGREHWNEMLTYPRKPIAHWHPLVEYHST 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	29/150 (19%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	64/125 (51%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	74/134 (55%)
syt9a	XP_001336058.4	C2	257..381	CDD:301316	64/124 (52%)
syt9a	XP_001336058.4	C2B_Synaptotagmin-3-5-6-9-10	390..523	CDD:176048	73/132 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820