DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt15

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_009305102.1	Gene:	syt15 / 798021	ZFINID:	ZDB-GENE-090527-2	Length:	435	Species:	Danio rerio

Alignment Length:	311	Identity:	91/311 - (29%)
Similarity:	150/311 - (48%)	Gaps:	33/311 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDM 224
            |||     ::||:.:|.|...|....|..:.    ||.|.|.|..:...|.|::::|..||....
Zfish   138 LGS-----IRPDLYQLPEEPSEWALPDGSAV----RLWFALRYQQDKEQLVVSLLRAANLPTQCQ 193

  Fly   225 GGTSDPYVKVYLLP-DKKKKFETKVHRKTLSPVFNETFTFK-SLPYADAMNKTLVFAIFDFDRFS 287
            ...:  .||:.||| |.::..:.|..||...|.||:||.|: |....|..  :|..::|..|...
Zfish   194 RNIT--LVKLQLLPSDDRRHRQAKARRKGCHPQFNDTFVFQVSNSCVDQC--SLNMSLFTVDHQK 254

  Fly   288 KHDQIGEVKVPLCTIDLAQTI--EEWRDLVSVEGEGGQ--EKLGDICFSLRYVPTAGKLTVVILE 348
            ||..:|::.:||...:|.:..  .:||||   :.|..|  .|.|||..||.|..:..:||||:|.
Zfish   255 KHHLMGQILIPLICSELKEAAGKVQWRDL---DNESDQPLSKNGDIQVSLNYNQSLHRLTVVVLR 316

  Fly   349 AKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVT 413
            |:.|:......:.   .|:.:..:.:.::.|.|::.|.. :|.:||..:|.:...|:...||.:.
Zfish   317 ARGLQCCSEAAVC---AKVCLKIHTQVVRNKWTTVAKGN-SPSFNEKLTFRLLPMQLDTACLSLQ 377

  Fly   414 VVDYDRIGTSEPI--GRCILG--CMGTGTELRHWSDMLASPRRPIAQWHTL 460
            :   .:..|.:|:  ...::|  ....|.||.||:||::.|:..:.|||.|
Zfish   378 I---QQPSTEKPVLLAIVVIGPFMYARGRELEHWNDMVSKPQELVRQWHPL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	40/127 (31%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	39/139 (28%)
syt15	XP_009305102.1	C2A_Synaptotagmin-15-17	164..285	CDD:176036	40/127 (31%)
syt15	XP_009305102.1	C2B_Synaptotagmin-15	294..426	CDD:176054	39/139 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820