DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Pla2g4d

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001019308.1	Gene:	Pla2g4d / 78390	MGIID:	1925640	Length:	825	Species:	Mus musculus

Alignment Length:	149	Identity:	43/149 - (28%)
Similarity:	71/149 - (47%)	Gaps:	6/149 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273
            |.|.:::|..||..|:...:||||.|.|......||:|:....:..||:||||:|  |..:...|
Mouse    33 LTVKILEARSLPRADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSF--LIQSQVKN 95

  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPT 338
             .|...|:|.|..:|.|...:|...:..|...|.:::   ..|:..:|.:|...::.....:.|.
Mouse    96 -ILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQK---TFSLNPQGPEELDVELLMERTWDPP 156

  Fly   339 AGKLTVVILEAKNLKKMDV 357
            ...:|..:|.|:.|..:||
Mouse   157 ENLITNNVLVARELSHLDV 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	33/106 (31%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	7/32 (22%)
Pla2g4d	NP_001019308.1	C2_cPLA2	32..151	CDD:176001	36/123 (29%)
		Patatin_and_cPLA2	278..814	CDD:299702
		PLAc	283..758	CDD:214474
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q86XP0	339..340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900