DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and sytl1

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001122005.1	Gene:	sytl1 / 777759	ZFINID:	ZDB-GENE-060503-439	Length:	539	Species:	Danio rerio

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	168/391 - (42%)	Gaps:	95/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KSVQLLGSAYKEKVQPDMEELTENAE---------------EGDEEDKQSEQKL----------- 193
            |..::|||.:::.|     |.:||.|               |||.:...:|...
Zfish   160 KRNEILGSGFEDSV-----EESENKERRILPSTSPTLQIDSEGDIDSGSTEINYTRFGSVTSLTS 219

  Fly   194 -----------------------GRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVY 235
                                   ||:.|.|:||..:..|.|.:|:.::| |......||||||||
Zfish   220 HHMMNGSLMSLYSVGDFGDVVVSGRIQFSLQYDVRTEELYVHIIRCQDL-ASARKNRSDPYVKVY 283

  Fly   236 LLPD--KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVP 298
            ||||  .:.|.:|.|.||||:||::||.|:| :...|...:.|..:::..:|..::..:||::|.
Zfish   284 LLPDNTSRSKKKTAVRRKTLNPVYDETMTYK-VRRLDLPARVLSMSVWHMERMRRNLFLGELEVR 347

  Fly   299 LCTIDLAQTIEEWRDL---VSVEGEGGQEKLGDICFSLRYV---------PTAGKLTVVILEAKN 351
            |...|.:|....|::|   |.:..|....: |.|.||:::|         |..|:|.:.:.|...
Zfish   348 LGQWDWSQNQPTWQNLQPRVQLSPEAIISR-GTILFSIKFVPPGSEGRGNPATGELHIWLREIVG 411

  Fly   352 L---KKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKI--CLV 411
            |   |:    |..:.|||..::.:...:..::|.:.:.:::|.:|.:..:: .|:....|  |..
Zfish   412 LLPTKR----GAPNTYVKSVVLPDESGVSGQQTRVVRGSVSPVFNHTMVYD-GFQSSDLIQACAE 471

  Fly   412 VTV--------VDYDRIGTSEPI--GRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEET 466
            :||        :...|:.|...:  |:.:.....|..|:..||.::.||.    .|.....|..|
Zfish   472 ITVWNPHPSGCLGGVRLSTGSGLSYGQSVCWMDSTEDEINVWSSVIQSPN----SWVDTSLPIRT 532

  Fly   467 D 467
            :
Zfish   533 N 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	47/162 (29%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	33/158 (21%)
sytl1	NP_001122005.1	PHD_SF	12..>43	CDD:304600
		C2A_SLP-1_2	242..364	CDD:176039	46/123 (37%)
		C2B_SLP_1-2-3-4	377..531	CDD:175987	34/163 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810