DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and SYT5

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_003171.2	Gene:	SYT5 / 6861	HGNCID:	11513	Length:	386	Species:	Homo sapiens

Alignment Length:	355	Identity:	194/355 - (54%)
Similarity:	270/355 - (76%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEE 174
            :|.|.:..|:::..|::|...|...|:..::|..|..:.:..|.::.|:.||.:|.:||||::||
Human    27 VPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEE 91

  Fly   175 LTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPD 239
            | |.|..|..:....:.:||||.:.|:|||.|..|.|.::||..|.|||:||:|||||:||||||
Human    92 L-EPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPD 155

  Fly   240 KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDL 304
            |::::||||||:||:|.|.|||.|| :||.:...:.||.|::||||||::|.||||:||:.::||
Human   156 KRRRYETKVHRQTLNPHFGETFAFK-VPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDL 219

  Fly   305 AQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAI 369
            .:.::.||:|.:...| .||||||||||||||||||||||::||||||||||||||||||||:.:
Human   220 GRPVQAWRELQAAPRE-EQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHL 283

  Fly   370 MQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCM 434
            :|.||:::||||:|||.||||||||:||||||.:|:||:.:.:||:|||::|.:|.|||..:|..
Human   284 LQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAA 348

  Fly   435 GTGTELRHWSDMLASPRRPIAQWHTLKDPE 464
            ..|..||||:||||:|||||||||:|:.|:
Human   349 AGGAGLRHWADMLANPRRPIAQWHSLRPPD 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	6/25 (24%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	69/123 (56%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	95/134 (71%)
SYT5	NP_003171.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2A_Synaptotagmin-1-5-6-9-10	109..231	CDD:176031	69/122 (57%)
		C2	240..374	CDD:387358	95/133 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3696
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.890