Protein Alignment Syt1 and SYT4

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_065834.1
• Gene: SYT4 / 6860
• HGNCID: 11512
• Length: 425
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 151/435 - (34%)
• Similarity: 218/435 - (50%)
• Gaps: 73/435 - (16%)

  Fly    88 PVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTK-------- 144
            |:....|...|:.|.|          |:.:...|||.|.......|.|:..|..:|.
Human     3 PITTSREEFDEIPTVV----------GIFSAFGLVFTVSLFAWICCQRKSSKSNKTPPYKFVHVL 57

  Fly   145 ----------DGKGKKG-------------------VDMKSVQLLGSAYKEKVQPDMEELTENAE 180
                      :.|.|.|                   :|::...|.|:..|..::|......|||.
Human    58 KGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLENAT 122

  Fly   181 -----EGDEE--------------DKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALD-MG 225
                 ||::|              .::.::|||.|.|.|||:|...:..|.:.:|..|||:| ..
Human   123 PKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQS 187

  Fly   226 GTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHD 290
            .|||||:|:.:||:||.|.:|:|.||||.|.|:|||||..:||.......|.|.|..|||||:.|
Human   188 MTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDD 252

  Fly   291 QIGEVKVPLCTIDLAQ-TIEEWRDLV--SVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNL 352
            .||||.:||..|:|:: .:...|:::  :|....|:   |::..||.|..|...||||:|:|::|
Human   253 IIGEVLIPLSGIELSEGKMLMNREIIKRNVRKSSGR---GELLISLCYQSTTNTLTVVVLKARHL 314

  Fly   353 KKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDY 417
            .|.||.||||||||:.:....||:.||||.:||||.|..:||.|.|::|.|.::.|.:...|:|.
Human   315 PKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDS 379

  Fly   418 DRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKD 462
            :|...:|.||:.:||....||...||.::...|||.||:||.|.|
Human   380 ERGSRNEVIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWHVLCD 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	19/109 (17%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	59/127 (46%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	60/134 (45%)
SYT4	NP_065834.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..93		1/19 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..147		3/19 (16%)
		C2A_Synaptotagmin-4-11	153..279	CDD:176034	59/125 (47%)
		C2B_Synaptotagmin-4	288..423	CDD:176049	60/137 (44%)