DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syt1 and SYT1

DIOPT Version :9

Sequence 1:NP_523460.2 Gene:Syt1 / 33473 FlyBaseID:FBgn0004242 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_001129277.1 Gene:SYT1 / 6857 HGNCID:11509 Length:422 Species:Homo sapiens


Alignment Length:443 Identity:252/443 - (56%)
Similarity:306/443 - (69%) Gaps:32/443 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGE 98
            :.|:||           |.||             ....|..||.....:|..|.|...|.:...:
Human     2 VSESHH-----------EALA-------------APPVTTVATVLPSNATEPASPGEGKEDAFSK 42

  Fly    99 VVTEVIAE--RTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTKDGK---GKKGVDMKSV 157
            :..:.:.|  :..||.|.::||.|:..|:|....| .|.:...||:..|.||   ||..::||.|
Human    43 LKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDV 107

  Fly   158 QLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPAL 222
            :.||...|::...|.:..|...:..::|:.:.|:|||:|.:.|:|||.:|.|.|.:|||.|||||
Human   108 KDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPAL 172

  Fly   223 DMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFS 287
            ||||||||||||:||||||||||||||||||:|||||.|||| :||::...||||.|::||||||
Human   173 DMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFS 236

  Fly   288 KHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNL 352
            |||.|||.|||:.|:|.....||||||.|.|.| .||||||||||||||||||||||||||||||
Human   237 KHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKE-EQEKLGDICFSLRYVPTAGKLTVVILEAKNL 300

  Fly   353 KKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDY 417
            |||||||||||||||.:||||||||||||:|||.|||||||||||||||||||||:.:||||:||
Human   301 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDY 365

  Fly   418 DRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEIL 470
            |:||.::.||:..:|...||.||||||||||:|||||||||||:..||.|.:|
Human   366 DKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAML 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt1NP_523460.2 Podoplanin 5..136 CDD:283467 24/104 (23%)
C2A_Synaptotagmin-1-5-6-9-10 192..316 CDD:176031 88/123 (72%)
C2B_Synaptotagmin-1 326..461 CDD:176047 112/134 (84%)
SYT1NP_001129277.1 Syt1_N 6..113 CDD:409248 35/130 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..142 5/28 (18%)
Phospholipid binding. /evidence=ECO:0000305 136..382 185/247 (75%)
C2A_Synaptotagmin-1-5-6-9-10 143..265 CDD:176031 87/122 (71%)
C2B_Synaptotagmin-1 274..409 CDD:176047 112/134 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 173 1.000 Domainoid score I3696
eggNOG 1 0.900 - - E1_KOG1028
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4122
Inparanoid 1 1.050 468 1.000 Inparanoid score I1535
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48342
OrthoDB 1 1.010 - - D394604at33208
OrthoFinder 1 1.000 - - FOG0000025
OrthoInspector 1 1.000 - - otm41141
orthoMCL 1 0.900 - - OOG6_106413
Panther 1 1.100 - - O PTHR10024
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4219
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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