Protein Alignment Syt1 and SYT1

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_005630.1
• Gene: SYT1 / 6857
• HGNCID: 11509
• Length: 422
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 252/443 - (56%)
• Similarity: 306/443 - (69%)
• Gaps: 32/443 - (7%)

  Fly    34 LEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGE 98
            :.|:||           |.||             ....|..||.....:|..|.|...|.:...:
Human     2 VSESHH-----------EALA-------------APPVTTVATVLPSNATEPASPGEGKEDAFSK 42

  Fly    99 VVTEVIAE--RTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTKDGK---GKKGVDMKSV 157
            :..:.:.|  :..||.|.::||.|:..|:|....| .|.:...||:..|.||   ||..::||.|
Human    43 LKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDV 107

  Fly   158 QLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPAL 222
            :.||...|::...|.:..|...:..::|:.:.|:|||:|.:.|:|||.:|.|.|.:|||.|||||
Human   108 KDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPAL 172

  Fly   223 DMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFS 287
            ||||||||||||:||||||||||||||||||:|||||.|||| :||::...||||.|::||||||
Human   173 DMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFS 236

  Fly   288 KHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNL 352
            |||.|||.|||:.|:|.....||||||.|.|.| .||||||||||||||||||||||||||||||
Human   237 KHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKE-EQEKLGDICFSLRYVPTAGKLTVVILEAKNL 300

  Fly   353 KKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDY 417
            |||||||||||||||.:||||||||||||:|||.|||||||||||||||||||||:.:||||:||
Human   301 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDY 365

  Fly   418 DRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEIL 470
            |:||.::.||:..:|...||.||||||||||:|||||||||||:..||.|.:|
Human   366 DKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAML 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	28/104 (27%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	88/123 (72%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	112/134 (84%)
SYT1	NP_005630.1	Syt1_N	6..113	CDD:409248	35/130 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..142		5/28 (18%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		185/247 (75%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	87/122 (71%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	112/134 (84%)