DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Doc2a

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_075226.1	Gene:	Doc2a / 65031	RGDID:	620518	Length:	403	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	116/332 - (34%)
Similarity:	157/332 - (47%)	Gaps:	42/332 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALD 223
            |||:     ..||      :..|.|..|......||.|.|.|.||..|..|...:::|:.|..:|
  Rat    70 LLGA-----TTPD------DGAEVDSYDSDDTTALGTLEFDLLYDQASCMLHCRILRAKGLKPMD 123

  Fly   224 MGGTSDPYVKVYLLPD--KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRF 286
            ..|.:|||||::|||.  |..|.:||..|.||:||:||..|:..:...|..:|.|..::.|.|:.
  Rat   124 FNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTYSGITDDDITHKVLRISVCDEDKL 188

  Fly   287 SKHDQIGEVKVPLCTIDLAQ------TIEEWRDLVS---------------------VEGEGGQE 324
            |.::.|||::|||..:..:|      .:|....|.|                     .:|.|..|
  Rat   189 SHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLPSPSSMSAALRGISCYLKELEQAEQGPGLLE 253

  Fly   325 KLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLN 389
            :.|.|..||.|......|.|.|:...:|..|||.|.||||||..:..:..:..|.||.:||.|||
  Rat   254 ERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLN 318

  Fly   390 PYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDMLASPRRP 453
            |.:||.|.:|:....:....|.|||.||| ||.|.. ||...||....|...:||.|.|..|...
  Rat   319 PEFNEEFFYEMELSTLATKTLEVTVWDYD-IGKSNDFIGGVSLGPGARGEAQKHWRDCLHQPDTA 382

  Fly   454 IAQWHTL 460
            :.:||||
  Rat   383 VERWHTL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	48/131 (37%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	56/136 (41%)
Doc2a	NP_075226.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..92		8/32 (25%)
		C2A_Rabphilin_Doc2	93..216	CDD:176000	46/122 (38%)
		Interaction with UNC13D. /evidence=ECO:0000250	218..403		61/173 (35%)
		C2B_Rabphilin_Doc2	257..389	CDD:176030	53/132 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910