DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt10

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_113854.1	Gene:	Syt10 / 60567	RGDID:	62041	Length:	523	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	171/475 - (36%)
Similarity:	248/475 - (52%)	Gaps:	97/475 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PNAKSETDAKPEAE----PAP-ASEPA-------ADLESVDQKLEETHHSKFREVDRQEQEVLAE 55
            |....||:.|.|.|    ||| |.|||       .|:.:..|...:.|..|...|.||..:..:.
  Rat   104 PTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTDPTSS 168

  Fly    56 KAAEAASQRIAQ---VESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVA 117
            ....:..:.:.:   |.|...|..||         ||:::    ||..|.:..
  Rat   169 SRHNSFRRHLPRQMNVSSVDFSMGTE---------PVLQR----GETRTSIGR------------ 208

  Fly   118 IIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEG 182
                            ::..|.|:::.|.:|.:..|:|:
  Rat   209 ----------------IKPELYKQKSVDSEGNRKDDVKT-------------------------- 231

  Fly   183 DEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETK 247
                      .|:|||.|:||:.:..|.|.:|:|.:|||.|..||||||||:|||||:||||:|:
  Rat   232 ----------CGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTR 286

  Fly   248 VHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVP-LCTI-DLAQTIEE 310
            ||||||:|:|:|.|.| .:.|....|:.|.|:|:||||||:||.||||.:. |..: ||::....
  Rat   287 VHRKTLNPLFDELFQF-PVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATV 350

  Fly   311 WRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKR 375
            |:|:.....|  ...||:|.|||.|:||||::|:.:::.:|||.||:.|.||||||:::|..|:|
  Rat   351 WKDIHCATTE--SIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRR 413

  Fly   376 LKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTEL 440
            |||:||:.||.||||.|||:..|::|.|.:.::.|.:.|:||||:|.:|.||.|..|....|...
  Rat   414 LKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGR 478

  Fly   441 RHWSDMLASPRRPIAQWHTL 460
            .||::|||..|:||..||.|
  Rat   479 DHWNEMLAYHRKPITHWHPL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	29/145 (20%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	66/125 (53%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	68/135 (50%)
Syt10	NP_113854.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	13..35
		C2A_Synaptotagmin-1-5-6-9-10	231..356	CDD:176031	66/161 (41%)
		C2B_Synaptotagmin-3-5-6-9-10	365..498	CDD:176048	66/132 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820