DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt8

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_445777.2	Gene:	Syt8 / 60566	RGDID:	68399	Length:	387	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	155/393 - (39%)
Similarity:	223/393 - (56%)	Gaps:	31/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 STTTAVPVIKKIEHVGEVVTEVIAERTGLPTW----GVVAIIILVFLVVFGIIFFCVRRFLKKRR 142
            ||:..|........:.:::|::     ..|.|    .::|..:|:...:..:|.:|..|   :|.
  Rat     9 STSAPVDATAGPNLIPDLITKI-----PWPRWILFIAILAAGVLLVSCLLCVICYCCHR---QRH 65

  Fly   143 TKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSN 207
            .|..|.|:.|.:.|.:  .|.....||||:|.| |....||       |..|:|...|||||.|.
  Rat    66 RKQPKDKETVGLGSAR--NSTTTHLVQPDVECL-EPCSGGD-------QPWGQLLLSLEYDFGSQ 120

  Fly   208 SLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAM 272
            .:.|.:.||:.|.|   .||:|||.:|.:.....::.||||||.||.|:|.||..| .:|.|:..
  Rat   121 EIRVGLRQAKNLKA---EGTADPYARVSVSTQAGRRHETKVHRGTLCPMFEETCCF-LVPPAELP 181

  Fly   273 NKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVP 337
            ..||...:.||.|||:|:.:||:::||.|:||...:|.|..| ...|....|::|::||||||||
  Rat   182 KATLKVQLLDFKRFSEHEPLGELQLPLGTVDLQHVLESWYQL-GPPGSTESEQMGELCFSLRYVP 245

  Fly   338 TAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPF 402
            ::|:||||||||:.|..    ||::.|||:.::.|.::.||.|||.||.|.|||:||:|.|.||.
  Rat   246 SSGRLTVVILEARGLNP----GLAEAYVKVQLILNQRKWKKNKTSSKKGTTNPYFNEAFVFLVPV 306

  Fly   403 EQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETD 467
            .|:|.:.||:.|........:||:|:.:||...:|..|:||:||||..||||||||.|:.|.|.|
  Rat   307 SQLQSMDLVLAVWARGLQLLAEPVGKVLLGPRASGQPLQHWADMLAHARRPIAQWHHLRSPREVD 371

  Fly   468 EIL 470
            ..|
  Rat   372 RAL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	10/57 (18%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	52/123 (42%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	68/134 (51%)
Syt8	NP_445777.2	Syt1_2_N	<27..72	CDD:425364	11/52 (21%)
		C2	107..225	CDD:417471	52/122 (43%)
		C2	234..364	CDD:417471	68/133 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880