DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Syt6

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_038958947.1	Gene:	Syt6 / 60565	RGDID:	62012	Length:	535	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	140/310 - (45%)
Similarity:	213/310 - (68%)	Gaps:	13/310 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 KVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPY 231
            :::|::.:  :.:.:|||...::.:..|::||.|.||:.|.:|.|.:::|.:|||.|..|:||||
  Rat   213 RIKPELYK--QKSVDGDEAKSEAAKSCGKINFSLRYDYESETLIVRILKAFDLPAKDFCGSSDPY 275

  Fly   232 VKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVK 296
            ||:|||||:|.|.:|:||||||:|.|:|.|.| .:||.:..::.|..::|||||||:||.||||.
  Rat   276 VKIYLLPDRKCKLQTRVHRKTLNPTFDENFHF-PVPYEELADRKLHLSVFDFDRFSRHDMIGEVI 339

  Fly   297 VP--LCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGG 359
            :.  ....||::....|:|:.....|  ...||:|.|||.|:||||:||:.:::.:|||.||:.|
  Rat   340 LDNLFEASDLSRETSIWKDIQYATSE--SVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITG 402

  Fly   360 LSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSE 424
            .||||||::::.:|:|||||||:|||.||||.|||:..|::|.|.:.::.|:::|:||||:|.:|
  Rat   403 YSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNE 467

  Fly   425 PIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK 474
            .||.|.:|....|....||::|||.||:|||.||.|.      |:.|:.|
  Rat   468 IIGVCRVGISAEGLGRDHWNEMLAYPRKPIAHWHCLA------EVKKSFK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	60/125 (48%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	71/134 (53%)
Syt6	XP_038958947.1	C2A_Synaptotagmin-1-5-6-9-10	237..361	CDD:176031	60/124 (48%)
Syt6	XP_038958947.1	C2B_Synaptotagmin-3-5-6-9-10	370..503	CDD:176048	70/132 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820