DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Syt9

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_038944965.1	Gene:	Syt9 / 60564	RGDID:	621169	Length:	566	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	145/306 - (47%)
Similarity:	206/306 - (67%)	Gaps:	12/306 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 QLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPAL 222
            ||.|..   :::|::.:  :.:.:.|:..:.:.:..|:|||.|:||.:...|.|.:.:|..|||.
  Rat   191 QLTGIG---RIKPELYK--QRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAK 250

  Fly   223 DMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFS 287
            |..||||||||:|||||:|.|.:||||||||:|||:|.|.| .:.|.|...:.|.|:::||||||
  Rat   251 DFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLF-PVHYNDLEARKLHFSVYDFDRFS 314

  Fly   288 KHDQIGEVKVPLCTIDLAQTIEE---WRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEA 349
            :||.||:|.|. ...|||....|   |:|:..|..:  ...||::.|||.|:||||:||:.|::|
  Rat   315 RHDLIGQVVVD-HFFDLADFPRECILWKDIEYVTND--NVDLGELMFSLCYLPTAGRLTITIIKA 376

  Fly   350 KNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTV 414
            :|||.||:.|.||||||:::|.:|:||||:|||.|:.||||.|||:..|:||.|.|.:|.|.:.|
  Rat   377 RNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAV 441

  Fly   415 VDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            :||||:|.:|.||.|.:|.........|||:||:.||:|||.||:|
  Rat   442 MDYDRVGHNEVIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	65/126 (52%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	74/135 (55%)
Syt9	XP_038944965.1	C2	221..345	CDD:417471	65/125 (52%)
Syt9	XP_038944965.1	C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	72/132 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820