DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and SYT13

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_065877.1	Gene:	SYT13 / 57586	HGNCID:	14962	Length:	426	Species:	Homo sapiens

Alignment Length:	321	Identity:	94/321 - (29%)
Similarity:	148/321 - (46%)	Gaps:	38/321 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SAYKEKVQPDMEELTENA--------EEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEE 218
            |..|.:|..::..|.:|.        |..:.|...|..:..:|::.|:||.....|.||.::|
Human   120 SRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEA-- 182

  Fly   219 LPALDMGGTSDPYVKVYLLPD----------KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273
             ...:..|..|.||:..:...          ||::..|......:.|:..|     .||.|
Human   183 -VTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEE-----ELPTA---- 237

  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDL--VSVEGEGGQEKLGDICFSLRYV 336
             ||...:...||||:|...||:::.|....:.....:|.:|  .:.|...|   .|::..|:.|:
Human   238 -TLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAG---AGEVLLSISYL 298

  Fly   337 PTAGKLTVVILEAKNLKKMDVGGL--SDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFE 399
            |.|.:|.||:::||||.......|  .|..||:.:....::||||:|...|..:||.:||...||
Human   299 PAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFE 363

  Fly   400 VPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            :|.:.:|...:.:.|:..|..|.|..:|.|.||...:|:|..||.:||.:|||.||.||.|
Human   364 LPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAMWHQL 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	32/135 (24%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	52/137 (38%)
SYT13	NP_065877.1	C2A_Synaptotagmin-13	160..277	CDD:176059	31/129 (24%)
SYT13	NP_065877.1	C2B_Synaptotagmin-13	288..425	CDD:176052	52/137 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820