DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and sytl2b

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_701277.6	Gene:	sytl2b / 572466	ZFINID:	ZDB-GENE-121214-363	Length:	1737	Species:	Danio rerio

Alignment Length:	557	Identity:	128/557 - (22%)
Similarity:	216/557 - (38%)	Gaps:	145/557 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PPNAKSETD-------AKPEAE------PAPASEP---AADLESVDQKL-----EETHHSKFREV 45
            ||.|:...|       :.||..      |...|.|   :.||::....|     .:|..:..:.:
Zfish  1225 PPVAEQVDDFICTSFTSSPETNHSCKCPPVKTSTPVHGSPDLQTRSGSLGHHLTTQTDGNIIKGI 1289

  Fly    46 DRQEQEVLAEKAAEAASQR------IAQVESTTR-----------------SATTEAQESTTTAV 87
            ..:|.|.|.:||.:.||.|      :..:.|..|                 :::|..|.|.:||.
Zfish  1290 QNRENESLIQKALKRASSRPVYHKSMEDISSIARQDQKLKQTDDYMHDNYDASSTHLQTSFSTAD 1354

  Fly    88 P------------VIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKK 140
            |            .::|....||..:| .:.|..:|.|.                        .:
Zfish  1355 PEHMKKLSKSVPSFLEKESDGGESDSE-SSSRGSVPKWN------------------------NR 1394

  Fly   141 RRTKDGKGKKGVDMKSVQ-LLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDF 204
            :.|..........:.||. .:.|.|                   ..|..|....|.:.|.|.|..
Zfish  1395 QFTNLSNYSGSTSLSSVSGSVASVY-------------------TSDYNSVDVQGSIQFSLNYVH 1440

  Fly   205 NSNSLAVTVIQAEELPALD-MGGTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFK-S 265
            ......:.|:|.:.|.|:| ....||||||.||:||...  |.:|.|.:|||:|.:||...:: .
Zfish  1441 KLREFHIFVVQCQNLAAVDAKRNRSDPYVKSYLIPDPANLGKRKTAVKKKTLNPTYNEILRYRVR 1505

  Fly   266 LPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEG--------- 321
            :.|  ..::.|..:.:..|.|.::..:||:::.|.|.|...|   .|.|:.::...
Zfish  1506 MEY--LTSQVLNLSAWHNDMFGRNSFLGEIELDLSTWDFNDT---ERKLLPLKPRNLFIQTTNSL 1565

  Fly   322 ------GQEKLGDICFSLRY---------VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQ 371
                  ||.:|     ::|:         ||.:|::.:.:.:.|||..:....: |||||..::.
Zfish  1566 QPSDLKGQMRL-----AIRFLPQISHSKNVPGSGEVHIWVKDCKNLPLIRSPTI-DPYVKCFVLP 1624

  Fly   372 NGKRLKKKKTSIKKCTLNPYYNESFSFE-VPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMG 435
            :..:..::||.:.|.|.||.:|.:..:: ...|.:::.|:.:||.|.||: .|..:|...|| ||
Zfish  1625 DTSKKSRQKTRVLKRTTNPIFNHTMVYDGFRAEDLKEACVELTVWDRDRL-ASHSLGGLRLG-MG 1687

  Fly   436 TGTELRHWSDMLASPRRPIAQW-HTLKDPEE-TDEIL 470
            ||.......|.:.|....:|.| ..:..|.| .::||
Zfish  1688 TGRSYGVQVDWMDSTTEEVALWRRMMNSPNEWVEDIL 1724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	34/186 (18%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	40/127 (31%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	39/145 (27%)
sytl2b	XP_701277.6	PHD_SF	5..>47	CDD:304600
		C2	1429..1553	CDD:301316	40/128 (31%)
		C2B_SLP_1-2-3-4	1571..1727	CDD:175987	45/162 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810