DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt2a

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_021325566.1	Gene:	syt2a / 567877	ZFINID:	ZDB-GENE-060503-315	Length:	430	Species:	Danio rerio

Alignment Length:	425	Identity:	230/425 - (54%)
Similarity:	304/425 - (71%)	Gaps:	12/425 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VLAEKAAEAASQRIAQVESTTR--SATTEAQESTTTAVPVIKKIEHVGEVVTEVIAE--RTGLPT 112
            ||.:|.|...........:.|.  :.:|.|..||....||.|. :..|::..:.:.|  :..||.
Zfish     5 VLKKKPAAMVGPEPTGASALTMAPAVSTPADNSTEHQGPVSKN-DVFGDIKNKFLNEMDKLPLPP 68

  Fly   113 WGVVAIIILVFLVVFGIIFFCVRR-FLKKRRTKDG-KGKKGVDMKSVQLLGSAYKEKVQPDMEEL 175
            |.::||.|:..:::....|..|:: .|||::.|.| |||..:.||:::   ...|::...|.|::
Zfish    69 WAIIAIAIVAVVLILTCCFCIVKKTCLKKKKGKKGKKGKGDMGMKNMK---GGEKQEEDDDEEDI 130

  Fly   176 TENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDK 240
            .....|..||:.:.::|||:|.|.|:|||:::.|.|.::||.:|.::|.||||||||||::||||
Zfish   131 DMGITEEKEEEPKEKEKLGKLQFSLDYDFSASQLTVGILQAADLLSMDSGGTSDPYVKVFILPDK 195

  Fly   241 KKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLA 305
            |||::||||:|||:|||||||.|| :|:.:...||||.:::|||||||||.|||||:|:.|:|||
Zfish   196 KKKYDTKVHKKTLNPVFNETFHFK-IPFTEMGGKTLVMSVYDFDRFSKHDVIGEVKIPMNTLDLA 259

  Fly   306 QTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIM 370
            |.||:||||.|.|.| ..|||||||.||||||||||||:.||||||||||||||||||||||.::
Zfish   260 QPIEQWRDLDSAEKE-EPEKLGDICISLRYVPTAGKLTICILEAKNLKKMDVGGLSDPYVKIHLL 323

  Fly   371 QNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMG 435
            |||||||||||::||.|||||||||||||:|.:|:|||..|:||:|||:||.::.||:..:|...
Zfish   324 QNGKRLKKKKTTVKKNTLNPYYNESFSFEIPQDQMQKIQAVITVLDYDKIGKNDAIGKIWVGSKA 388

  Fly   436 TGTELRHWSDMLASPRRPIAQWHTLKDPEETDEIL 470
            .||||||||||||:|||||||||.||..||.|..|
Zfish   389 QGTELRHWSDMLANPRRPIAQWHPLKPEEEVDATL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	22/87 (25%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	79/123 (64%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	102/134 (76%)
syt2a	XP_021325566.1	C2A_Synaptotagmin-1-5-6-9-10	148..270	CDD:176031	78/122 (64%)
syt2a	XP_021325566.1	C2B_Synaptotagmin-1	279..414	CDD:176047	102/134 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3597
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1541
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm25172
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.940