DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt5b

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001018382.2	Gene:	syt5b / 553567	ZFINID:	ZDB-GENE-050522-134	Length:	446	Species:	Danio rerio

Alignment Length:	468	Identity:	228/468 - (48%)
Similarity:	297/468 - (63%)	Gaps:	77/468 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSA 75
            |:||.||.|  ||.:..|........|||    :.|..:.:.:.|
Zfish    45 AEPEPEPEP--EPHSKPEHRPHPAPPTHH----DYDNMKSKFMNE-------------------- 83

  Fly    76 TTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCV--RRFL 138
                             :||:            .||.|.|.||:::| |.:.....:|:  :.|.
Zfish    84 -----------------LEHL------------PLPMWAVGAIVVVV-LALVACFTYCMFKKCFG 118

  Fly   139 KKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQ-PDMEELTENAEEGD----EEDKQSEQKLGRLNF 198
            ||:::|..:.:|           .|.::||: .:.|...|..:||:    ||.|:..:.||:|.|
Zfish   119 KKKKSKKARERK-----------RAARKKVEGTEGEGQGEQKDEGEKKEGEEQKEEHENLGKLEF 172

  Fly   199 KLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTF 263
            .|:|:|....|.|.::||::|.|:|:||||||||||||||||||||||||.||.|.|||||||.|
Zfish   173 SLDYNFTDAQLIVGILQAQDLAAMDIGGTSDPYVKVYLLPDKKKKFETKVQRKNLCPVFNETFIF 237

  Fly   264 KSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGD 328
            | :|||:...||||..:||||||.|||.||::|:|:..:||||.:.|||:|.:  ||..:|||||
Zfish   238 K-IPYAELGGKTLVLQVFDFDRFGKHDVIGQIKIPMNCVDLAQPLHEWRELEN--GEKEEEKLGD 299

  Fly   329 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYN 393
            :|.|||||||||||||.|:||||||||||||||||||||.:..||||||||||::||.|||||:|
Zfish   300 VCISLRYVPTAGKLTVNIMEAKNLKKMDVGGLSDPYVKIVLQHNGKRLKKKKTTVKKNTLNPYFN 364

  Fly   394 ESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWH 458
            ||||||||||||||:.|::||.|||::|:::|||:..:|...||..|||||||||:||||:||||
Zfish   365 ESFSFEVPFEQIQKVQLLITVYDYDKLGSNDPIGKTFIGYGATGVGLRHWSDMLANPRRPVAQWH 429

  Fly   459 TLKDPEETDEILK 471
            ||:..||.:..||
Zfish   430 TLQPEEEVEAALK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	25/126 (20%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	78/123 (63%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	101/134 (75%)
syt5b	NP_001018382.2	C2A_Synaptotagmin-1-5-6-9-10	166..285	CDD:176031	75/119 (63%)
syt5b	NP_001018382.2	C2B_Synaptotagmin-1	298..432	CDD:176047	100/133 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3947
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1541
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.930