Protein Alignment Syt1 and sytl4

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001074457.1
• Gene: sytl4 / 553322
• ZFINID: ZDB-GENE-070209-217
• Length: 689
• Species: Danio rerio
• Alignment Length: 548
• Identity: 131/548 - (23%)
• Similarity: 218/548 - (39%)
• Gaps: 123/548 - (22%)

  Fly    20 ASEPAADLESVD---QKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQE 81
            :|.|..||..|.   :.|.:.|.:. .|:...:.|:...:||.....|:..:....:|:..|.:|
Zfish   130 SSAPGHDLVRVSLRKRPLSKKHETA-GEILLNKVELNTSQAAPVPKPRLKDIALANKSSLLEGEE 193

  Fly    82 STTTAVPVIKKI----EHVGEVVTEVIAE-------RTGLPTWGVVAIIILVF------LVVFGI 129
            ...:....|:|.    :|.....:....:       |...|....|:|::...      .:....
Zfish   194 GQQSDTESIEKASLDSDHAETKFSHSTPQMQRKEELRANSPEDCAVSILMSTVNSDSTATIETAS 258

  Fly   130 IFFCVRRFLKKRRTKDGKGKKGV-------DMKSVQLLG--SAYKEKVQPDMEELTE-----NAE 180
            :...:.......|..||..||.|       ::|....|.  ....|...|.|.:.::     ||:
Zfish   259 LIHHMNACSDSLRDVDGLFKKSVRRVHKLSEIKPASTLDLREDASENTTPSMGDRSKSVPGLNAD 323

  Fly   181 EGDEE---------------------------------------DKQSEQKLGRLNFKLEYDFNS 206
            :.:||                                       |....:..|.:.|.|.||..|
Zfish   324 DDEEEEDIDNLVNIHRQKFGSSMGSLGGSRTTLGSMMSVYSEAGDYDHVEVSGEIVFSLSYDEPS 388

  Fly   207 NSLAVTVIQAEELPALDMGGTS-DPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYAD 270
            .||:|.|.:.:.|...|..... :||||.||||||.|| :|.:....::|.|.||..: |:....
Zfish   389 QSLSVMVHECKGLAYADPAKKKCNPYVKAYLLPDKSKK-KTSIKHNNINPSFKETLKY-SISRTQ 451

  Fly   271 AMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKL--------G 327
            .|.:||..:::.:|||..:..:|||:|.:.:.|:....||   .:::.|:...:.|        |
Zfish   452 LMTRTLQLSVWHYDRFGHNAFLGEVEVLMDSYDIDSAHEE---CMALRGKAVPQSLLSPFDQYKG 513

  Fly   328 DICFSLRYV----PTA------GK---------LTVVILEAKNLKKMDVGGLSDPYVK-IAIMQN 372
            ::..||:||    |.|      ||         |.|:|.|||||..:..||..|.:|| ..:...
Zfish   514 ELVISLKYVTPNAPNAEDSKGKGKKSKPADGSELHVLIKEAKNLTALKAGGTCDSFVKGYLLPSK 578

  Fly   373 GKRLKKKKTSIKKCTLNPYYNESFSF-EVPFEQIQKICLVVTVVDYDRIGTSEPIG--RCILGCM 434
            .|...||||.:.|.|.:|.||.:|.: .:..::::.:||.:||.|.:.:.:::.:|  |..||.:
Zfish   579 SKSSSKKKTPVVKKTKSPNYNHTFVYNNLSLDELKDMCLELTVWDRETLSSNDFLGGVRLSLGAV 643

  Fly   435 ------------GTGTELRHWSDMLASP 450
                        .||.|:..|..|:..|
Zfish   644 TVKEGKEEWMADSTGEEILLWKKMMQYP 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	18/122 (15%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	43/124 (35%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	49/168 (29%)
sytl4	NP_001074457.1	PHD_SF	10..124	CDD:473978
		FYVE_Slp4	60..109	CDD:277303
		C2A_SLP-4_5	375..496	CDD:175995	43/125 (34%)
		C2B_SLP_1-2-3-4	512..682	CDD:175987	48/160 (30%)