DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Syt7

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_030106854.1	Gene:	Syt7 / 54525	MGIID:	1859545	Length:	719	Species:	Mus musculus

Alignment Length:	292	Identity:	134/292 - (45%)
Similarity:	198/292 - (67%)	Gaps:	4/292 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 DMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVY 235
            :|..|:..:||.:..:..|.:.|||:.|.:.|:|..::|.|.|::|:||||.|..|||||:||:|
Mouse   430 EMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIY 494

  Fly   236 LLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLC 300
            ||||||.|.||||.||.|:|.:||||.|:..||...:.:.|...:.|:||||::|.||||.:||.
Mouse   495 LLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRVLYLQVLDYDRFSRNDPIGEVSIPLN 559

  Fly   301 TIDLAQTIEEWRDLVSV-EGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPY 364
            .:||.|....|:||... :|.|.:   |::..||.|.|:|..:.|.|::|:|||.||:||.||||
Mouse   560 KVDLTQMQTFWKDLKPCSDGSGSR---GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPY 621

  Fly   365 VKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRC 429
            ||:.:|...||::||||..||..|||.:||||:|::|.|::::..:::||:|.|::..::.||:.
Mouse   622 VKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKI 686

  Fly   430 ILGCMGTGTELRHWSDMLASPRRPIAQWHTLK 461
            .|.......|::||.||:|.||:|:||||.||
Mouse   687 YLSWKSGPGEVKHWKDMIARPRQPVAQWHQLK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	64/123 (52%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	61/134 (46%)
Syt7	XP_030106854.1	PHA03307	138..>343	CDD:223039
		C2A_Synaptotagmin-7	451..575	CDD:176032	64/123 (52%)
		C2B_Synaptotagmin-7	583..718	CDD:176050	61/137 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820