DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and sytl1

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001006773.1	Gene:	sytl1 / 448459	XenbaseID:	XB-GENE-972182	Length:	518	Species:	Xenopus tropicalis

Alignment Length:	368	Identity:	97/368 - (26%)
Similarity:	164/368 - (44%)	Gaps:	62/368 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 TKDGKGK-KGVDMKSV-----------QLLGSAYKEKVQPDMEELTENAEEG------DEEDKQS 189
            |.|||.. :.:::..|           ::|.........|.:..||.|:..|      ...|.:|
Frog   153 TTDGKNSMEDINLSPVNGTITSGDTNGEILEGKENLNDSPPVPRLTNNSISGSMISLFSTGDMRS 217

  Fly   190 EQKLGRLNFKLEYDFNSNSLAVTVIQAEEL-PALDMGGTSDPYVKVYLLPDK--KKKFETKVHRK 251
            ....|.:.|.|:||.:...|.|.:||..:| ||  ...||:||:|.||||||  :.|.::||.:|
Frog   218 VDVQGCVQFSLQYDPSKKELNVLIIQCRDLTPA--QRKTSNPYIKCYLLPDKTVQGKRKSKVKKK 280

  Fly   252 TLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVS 316
            ||.|.||||..:| :..::..::.|..:::......::..:|||:|.|.:.|.::|...|.:|
Frog   281 TLEPFFNETLKYK-VERSELQSRVLNLSVWHRGSLGRNIFLGEVEVDLVSWDWSKTQPSWFNL-- 342

  Fly   317 VEGEGGQEKL----------GDICFSLRYV---------PTAGKLTVVILEAKNLKKMDVGGLSD 362
                  |.:.          |.|..:|:||         |..|:|.|.|.||:.|.....|.:|
Frog   343 ------QPRTPLSPDFLCSRGRISVALKYVPQGAEGLGLPPTGELHVWIKEARQLVPHKAGNVS- 400

  Fly   363 PYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFE-VPFEQIQKICLVVTVVDYDRIGTSEPI 426
            .:||..::.:......:.|.:...:|:|.:|.:..:: ...|.:::.|:..|:.|..:|| |..:
Frog   401 TFVKCFVLPDSVPSNFQNTRVIPHSLHPMFNHTMVYDGFSGEDLKEACVECTIWDQGKIG-SRSL 464

  Fly   427 GRCILGCMGTGTELR---HWSDMLASPRRPIAQWHT-LKDPEE 465
            |...|. .|.|:...   .|.|.....:   |.|.: :.:|.|
Frog   465 GGIRLS-TGKGSSYETSVSWMDSTVEEK---AFWESVINNPGE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	45/126 (36%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	36/158 (23%)
sytl1	NP_001006773.1	PHD_SF	20..>66	CDD:419867
		C2	221..343	CDD:417471	45/132 (34%)
		C2B_SLP_1-2-3-4	356..512	CDD:175987	38/154 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910