DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and syt1a

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001314758.1	Gene:	syt1a / 436736	ZFINID:	ZDB-GENE-040718-165	Length:	419	Species:	Danio rerio

Alignment Length:	426	Identity:	247/426 - (57%)
Similarity:	305/426 - (71%)	Gaps:	22/426 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SQRIAQVESTTRSATTEAQESTTTAV---PVIKKIEHVGEVVTEVIAE--RTGLPTWGVVAI-II 120
            |:|.|:|.:...:|..|...::|.|.   |...|.|...:|..:.:.|  :..||:|.:||| .:
Zfish     2 SRREARVGNPAPTAAPEVPGNSTEAAGPGPRETKDEMFSKVKNKFMNELHKIPLPSWAIVAIAFV 66

  Fly   121 LVFLVVFGIIFFCVRRFLKKRRTKDG--KGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEG- 182
            .|.|||......|.:...||:..|.|  |||..::||.|       |:.::.:..:..::||.|
Zfish    67 AVVLVVSCCFCICKKWIFKKKNKKKGKDKGKNAINMKDV-------KDGIKTEALKDEDDAETGL 124

  Fly   183 ----DEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKK 243
                .|.:.:.|:|||:|.:.::|:|..|:|.|.:|||.||||:|||||||||||||||||||||
Zfish   125 TDTEKEVEPKEEEKLGKLQYSMDYNFTENTLIVGIIQAAELPAMDMGGTSDPYVKVYLLPDKKKK 189

  Fly   244 FETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTI 308
            ||||||||||:|||||.|||| :||.:...||||..::|||||||||.||:||||:..:|.:...
Zfish   190 FETKVHRKTLNPVFNEQFTFK-VPYTELGGKTLVMTVYDFDRFSKHDAIGDVKVPMNKVDFSHVT 253

  Fly   309 EEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNG 373
            ||||||.|.|.| .|||||||||||||||||||||||:|||||||||||||||||||||.:||||
Zfish   254 EEWRDLQSAEKE-EQEKLGDICFSLRYVPTAGKLTVVVLEAKNLKKMDVGGLSDPYVKIHLMQNG 317

  Fly   374 KRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGT 438
            ||||||||:|||.|||||||||||||||||||||:.:|:||:|||:||.::.||:..:|...|||
Zfish   318 KRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVITVLDYDKIGKNDAIGKVFVGLNSTGT 382

  Fly   439 ELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK 474
            ||||||||||:|||||||||.||..||.|.:|...|
Zfish   383 ELRHWSDMLANPRRPIAQWHVLKPEEEVDALLAAQK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	24/79 (30%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	84/123 (68%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	110/134 (82%)
syt1a	NP_001314758.1	C2A_Synaptotagmin-1-5-6-9-10	139..261	CDD:176031	83/122 (68%)
syt1a	NP_001314758.1	C2B_Synaptotagmin-1	270..405	CDD:176047	110/134 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3597
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1541
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm25172
orthoMCL	1	0.900	-	-		OOG6_106413
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4219
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870