DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt4

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	139/413 - (33%)
Similarity:	205/413 - (49%)	Gaps:	99/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 FLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQ---------- 191
            :|||..:..|.       |.:.||.....:...|..:...:.:||||...:.:||
  Fly    74 YLKKSPSPTGG-------KQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVD 131

  Fly   192 -----------------------------------------------KLGRLNFKLEYDFNSNSL 209
                                                           |||.:.|||.|....|:|
  Fly   132 GNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNAL 196

  Fly   210 AVTVIQAEELPALDMGGTS-----------------DPYVKVYLLPDKKKKFETKVHRKTLSPVF 257
            .|::|:...||.  .||:|                 |||||:.|||||:.|.:|:|.|.|.:||:
  Fly   197 MVSIIRCRGLPC--KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVY 259

  Fly   258 NETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGG 322
            :|.|||..|...|..|.:|.|.|..|||:|:.|.||||..||.:|::....:|   .:|:..|..
  Fly   260 DEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE---ALSISKEIQ 321

  Fly   323 QEKL-------GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKK 380
            ...|       |::..||.:.|.||:||||:|:|:||.:|||.||:||||||.::.||:|:.|||
  Fly   322 PRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKK 386

  Fly   381 TSIKKCTLNPYYNESFSFEVPFEQ-----IQKICLVVTVVDYDRIGTSEPIGRCIL-GCMGTGTE 439
            |.:||.||:|.:||||:|::|..:     ::.:.|.:.::|:||:..:|.|||..| |...:.|.
  Fly   387 THVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTA 451

  Fly   440 LRHWSDMLASPRRPIAQWHTLKD 462
            |.||:::..||||.||:||.|.:
  Fly   452 LNHWNEVCNSPRRQIAEWHKLNE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	56/140 (40%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	66/147 (45%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	58/147 (39%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	65/140 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468159
Domainoid	1	1.000	68	1.000	Domainoid score	I3464
eggNOG	1	0.900	-	-		E1_KOG1028
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D69226at33392
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850