DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt4

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_956242.1	Gene:	syt4 / 335357	ZFINID:	ZDB-GENE-030131-7297	Length:	439	Species:	Danio rerio

Alignment Length:	453	Identity:	146/453 - (32%)
Similarity:	210/453 - (46%)	Gaps:	95/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFF---CVRRFLKKRRTKDGKGK 149
            ||..:..|..||...|              .::.||.:||.:..|   |.:|...|...|....|
Zfish     3 PVTTEEAHFAEVPVSV--------------AVVSVFGLVFSVSIFAWICCQRKANKSSNKTPPYK 53

  Fly   150 -----KGVDMKSVQLLGSAY-----------KEKVQP---------DMEELT------------- 176
                 ||||:....|.|...           |:.:.|         |:|:..
Zfish    54 FVHMLKGVDIYPESLSGKKKFGGEKTPEAHGKQTLSPTGGRPDLHLDLEKRDLNGNFTTKPPTLQ 118

  Fly   177 ------------------ENAEEGD--------------EEDKQSEQKLGRLNFKLEYDFNSNSL 209
                              .|.|.|.              |:.:..|..||.|.|.:||:|...:.
Zfish   119 LKVRSSPDIDIPALQGGFANQEAGTPESVVSSHTPTPAVEKSQDKEGGLGTLFFSVEYNFEKKAF 183

  Fly   210 AVTVIQAEEL-PALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273
            .|.:.:|..| |..:...|||||:|:.|||:||.|.:|:|.||||.|.|:|||:|..:|:|....
Zfish   184 MVHIKEAHGLSPTDEQSLTSDPYIKLTLLPEKKHKVKTRVLRKTLDPAFDETFSFYGIPFARVSQ 248

  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQ-TIEEWRDLV--SVEGEGGQEKLGDICFSLRY 335
            ..|.|.:..|||||:.:.|||..|||..|||:: .:...||::  ::....|:   |::..||.|
Zfish   249 LALHFMVLSFDRFSRDEVIGETLVPLADIDLSEGRVLMSRDIIKKNIRRSAGR---GELLLSLCY 310

  Fly   336 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEV 400
            ..|...||||:|:|::|.|.|..|.||||||:.:.|..||:.||||.:|||..||.:||.|.|::
Zfish   311 QSTTSTLTVVVLKARHLPKADSSGPSDPYVKVNLFQGKKRVCKKKTHVKKCAPNPVFNELFVFDL 375

  Fly   401 PFEQ-IQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKD 462
            |.|. ::...:.:.::|.||...:..|||.:||....||...||.::...|||.||:||.|.:
Zfish   376 PSEDGLRDTSVELLLLDSDRTSRTPVIGRLVLGTSSPGTAGEHWREICDHPRRQIAKWHALSE 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	12/50 (24%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	55/127 (43%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	58/135 (43%)
syt4	NP_956242.1	C2A_Synaptotagmin-4-11	166..292	CDD:176034	55/125 (44%)
syt4	NP_956242.1	C2B_Synaptotagmin-4	301..437	CDD:176049	58/138 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820