DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt12

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001259513.1	Gene:	Syt12 / 32290	FlyBaseID:	FBgn0261085	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	138/530 - (26%)
Similarity:	220/530 - (41%)	Gaps:	126/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPNAKSE------------TDAKPEAEP--APASEPAADLESVDQKLEETHHSKFREVDRQEQE 51
            :|.|..||            |.:..|..|  ||...|...: |.|.. ...||:....|:|
  Fly   281 IPSNPISEPLNATVASLEKTTISTSECTPITAPLETPNGPI-STDTP-STIHHNGNPFVER---- 339

  Fly    52 VLAEKAAEAASQRIAQVESTTRSATTEAQ--------ESTTTAVPVIKKI--------------- 93
                   |:.|.|:.::.:||...|..:|        :.|.:...:.:|:
  Fly   340 -------ESLSSRLLKIHNTTNPFTGLSQRVKGPHLLQKTISEDYLFRKLGVNCPMANGNGTGPG 397

  Fly    94 -EHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKD---GKGKKGVDM 154
             .||         ...|..||.            ||      |..|::..|..   |.|::
  Fly   398 SGHV---------NGNGNGTWS------------FG------RSLLRQDSTLSLGMGLGRR---- 431

  Fly   155 KSVQLLGSAYKEKVQPDMEELTENAEEG--------------DEEDKQSEQKLGRLNFKLEYDFN 205
            .|.|:...::...|...|:.:  |.|..              |:.|:...|..|.|...|.||..
  Fly   432 NSSQVSLDSHAGSVPGSMDGI--NLERAISCDSVTSDSTLFLDQLDQPYTQITGYLCVGLNYDQM 494

  Fly   206 SNS-----LAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKS 265
            |.|     |.|:|::|:.|.......:.|.:|::||:||.....:|||.:.||:|.:||:|.|
  Fly   495 SISNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDF-- 557

  Fly   266 LPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDIC 330
            ..:......:|.|.:  :.....|..|||.::.:.  ::.:.|..|..|  .:......:.|::.
  Fly   558 WLHKRQARHSLWFHL--YHNGPAHTLIGEAEMEIG--EMPRPITTWIPL--SDSRKCNARWGELM 616

  Fly   331 FSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDP---------YVKIAIMQNGKRLKKKKTSIKKC 386
            |||.|:|||.:||:|:::|:|| |:| |....|         :||:.:|...:::.||:||:|:.
  Fly   617 FSLSYLPTAERLTIVVVKARNL-KLD-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSLKRK 679

  Fly   387 TLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPR 451
            ..:|.:|||..|.||...:....|.|||......|.: |:|..:.|....|..||||..||:|.|
  Fly   680 DRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHIVAGSCAVGKGLRHWHQMLSSLR 743

  Fly   452 RPIAQWHTLK 461
            :|:|.||.|:
  Fly   744 KPVAMWHVLR 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	30/168 (18%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	37/128 (29%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	54/143 (38%)
Syt12	NP_001259513.1	C2	503..602	CDD:278593	29/104 (28%)
Syt12	NP_001259513.1	C2B_Synaptotagmin-12	612..753	CDD:176051	54/143 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850