DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Rph

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	95/314 - (30%)
Similarity:	145/314 - (46%)	Gaps:	43/314 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 TENAEEGDEEDKQSEQK-----LGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVY 235
            ::...:..:..:|.:|.     ||.|...:.|....:||..|:::|.:|||:|..|.:|||.|:.
  Fly   332 SQTQSQYQQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLN 396

  Fly   236 LL-PDKKKKF----ETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEV 295
            :: |:...|:    .||...||.:|.||||..|..:...:..|..:..|:||.|::. ||.:|..
  Fly   397 IITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAA 460

  Fly   296 KVPLCTI-------------------DLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGK 341
            ||.|.|:                   :.|:..:.|.:             |.:..||.|......
  Fly   461 KVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPN-------------GKMLLSLCYNTKRRA 512

  Fly   342 LTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQ 406
            |.|.:.:..||..||..|.|||:|||.:..:..:.||.|||:|..||||.|||.|.||.....:.
  Fly   513 LVVNVKQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLN 577

  Fly   407 KICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            |..|::||.|.|...:::.:|...||....|..|:.|.|.:..|.....:||.|
  Fly   578 KEMLILTVWDKDLGKSNDFLGSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	43/152 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	50/135 (37%)
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	41/123 (33%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	48/131 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
	5	4.840