DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Doc2g

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_006230797.1	Gene:	Doc2g / 293654	RGDID:	1307473	Length:	389	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	104/328 - (31%)
Similarity:	161/328 - (49%)	Gaps:	48/328 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 KVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEEL--PALDMGGTSD 229
            ::||:.|      .|||.:|..:   ||.|.|.|.:|.::::|..|..:|:.|  ||.   |:.|
  Rat    67 QLQPNPE------AEGDSDDSTA---LGTLEFTLLFDVDNSTLHCTAHRAKGLKPPAT---GSVD 119

  Fly   230 PYVKVYLLPDKKK----KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHD 290
            .|||..|||...|    :..|:..|.|..||:.||.|:......||..|||...:.:..|..:..
  Rat   120 TYVKANLLPGASKVRASQLRTRTVRGTREPVWEETLTYHGFTCQDAGRKTLRLCVCEDSRLRRRR 184

  Fly   291 Q---IGEVKVPL-------------C-----------TIDLAQTIEEWRDLVSVEGEGGQEKLGD 328
            :   :||::|||             |           ::|.|:.:..:.: ..||.|..:|:.|.
  Rat   185 RAPPLGELRVPLRKLVPNRARSFDICLEKRRLTKRPKSLDTARGMSLYEE-EEVEAEVFREERGR 248

  Fly   329 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYN 393
            |..||.|....|.|.|.:|...:|..||..|.|||:|::.:..:..:..|.|||:::.||||.:|
  Rat   249 ILLSLCYSSERGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPSSGKKSKYKTSVRRKTLNPEFN 313

  Fly   394 ESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDMLASPRRPIAQW 457
            |.|.:....|::.:..|:|:|.||| :||::. ||...|....:|..||||.:.|:...|.:..|
  Rat   314 EEFFYAGLREELAQKALLVSVWDYD-LGTADDFIGGVQLSGRSSGDRLRHWCECLSHCDRRLELW 377

  Fly   458 HTL 460
            |.|
  Rat   378 HLL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	43/156 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	50/136 (37%)
Doc2g	XP_006230797.1	C2A_Rabphilin_Doc2	84..211	CDD:176000	40/129 (31%)
Doc2g	XP_006230797.1	C2	248..380	CDD:301316	48/132 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910