DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and PLA2G4D

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_828848.3	Gene:	PLA2G4D / 283748	HGNCID:	30038	Length:	818	Species:	Homo sapiens

Alignment Length:	158	Identity:	44/158 - (27%)
Similarity:	74/158 - (46%)	Gaps:	24/158 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273
            |.|.|::|..|...|:...:||||.:.|......||:||....|..||:||.|.|  |..:...|
Human    24 LTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRF--LIQSQVKN 86

  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLC---TIDLAQTI--EEWRDLVSVEGEGGQEKLGDICFSL 333
             .|..:|:|.|..::.|        :|   ..|:::.:  :..|...| :...|:|:| |:.|.:
Human    87 -VLELSIYDEDSVTEDD--------ICFKVLYDISEVLPGKLLRKTFS-QSPQGEEEL-DVEFLM 140

  Fly   334 RYVPTAGK----LTVVILEAKNLKKMDV 357
            .  .|:.:    :|..::.|:.|..:||
Human   141 E--ETSDRPENLITNKVIVARELSCLDV 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	32/111 (29%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	9/36 (25%)
PLA2G4D	NP_828848.3	C2_cPLA2	23..141	CDD:176001	38/129 (29%)
		cPLA2_Grp-IVB-IVD-IVE-IVF	269..811	CDD:132840
		Substrate binding. /evidence=ECO:0000269\|PubMed:27220631, ECO:0007744\|PDB:5IXC, ECO:0007744\|PDB:5IZR	330..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900