DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Sytl1

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_113570.2	Gene:	Sytl1 / 269589	MGIID:	1933365	Length:	568	Species:	Mus musculus

Alignment Length:	503	Identity:	122/503 - (24%)
Similarity:	209/503 - (41%)	Gaps:	123/503 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TDAKPEA------EPAPASEPAADLESVDQKLE-----------ETHHSKFREVDRQEQEVLAE- 55
            :|.:.||      |..|.|..:.::.:.::..|           .:..|:.:|.:.|:||...|
Mouse   120 SDGEAEAAGENTIEGEPESRVSIEVAAPERNTETQGPDLFSPYVPSKASEGQEEEPQDQECELEA 184

  Fly    56 ------KAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGL-PTW 113
                  :.|||..:...:.::...|..|.||...|:      ||...||       |..|| |:
Mouse   185 PGEGGVQVAEADPELDPEQKAEQESQPTPAQSKATS------KILENGE-------EAPGLGPS- 235

  Fly   114 GVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTEN 178
                                :.|.|.             ...||..|.|:   .:...:..|:..
Mouse   236 --------------------LDRMLS-------------SSSSVSSLNSS---TLSGSLMSLSGE 264

  Fly   179 AEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKK 243
            ||.|      :.|..|.:.|.|.|:..::.|.|.|||.:.|.|. ....||||||.||||||:.|
Mouse   265 AEAG------TVQVRGSVLFSLRYEPGTSELRVQVIQCQGLAAA-RRRRSDPYVKSYLLPDKQSK 322

  Fly   244 FETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCT--IDLAQ 306
            .:|.|.::.|:|:||||.. .|:..||...:.|..:::..:...::..:|||:|||.|  .|...
Mouse   323 RKTSVKKRNLNPIFNETLR-HSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEA 386

  Fly   307 TIEEWRDLVSVEGEGGQE--KLGDICFSLRYVPT---------AGKLTVVILEAKNLKKMDVGGL 360
            |   |..|.........|  ..|.:..||:|||.         :|:|...:.||::|..:..|.|
Mouse   387 T---WLPLQPRVPPSPDELPSRGLLSLSLKYVPAGSEGGGQPQSGELHFWVKEAQSLVPLRPGSL 448

  Fly   361 SDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFE--VPFEQIQKICLVVTVVDYDRIGTS 423
             |.|::.:::.:..|..:::|.:.:.:|:|.:|.:..::  .|.: :::.|..:::.|:..: .|
Mouse   449 -DTYIQCSVLPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPAD-LRQACAELSLWDHGAL-AS 510

  Fly   424 EPIGRCILGCMGTGT--------------ELRHWSDMLASPRRPIAQW 457
            ..:|...|. :|||:              |.:.|..:|..|    .:|
Mouse   511 RQLGGTRLS-LGTGSSYGLQVPWMDSTPEEKQLWQTLLERP----CEW 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	29/151 (19%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	47/125 (38%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	34/157 (22%)
Sytl1	NP_113570.2	PHD_SF	35..>99	CDD:389947
		NESP55	<92..230	CDD:115071	26/122 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..255		35/184 (19%)
		C2	273..392	CDD:387358	46/123 (37%)
		C2B_SLP_1-2-3-4	405..561	CDD:175987	34/157 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810