DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt3

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_061995.1	Gene:	Syt3 / 25731	RGDID:	3805	Length:	588	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	166/440 - (37%)
Similarity:	232/440 - (52%)	Gaps:	105/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QRIAQVESTTR-----------SATTEAQESTTTAVPVI--------KKIEHVGEVVTEVIAERT 108
            |::..:..|||           :.||:|..|:....|.:        :|.:.:|::..|:.   .
  Rat   217 QQVTSLAPTTRYPALPRPLTQQTLTTQADPSSEERPPALPLPLPGGEEKAKLIGQIKPELY---Q 278

  Fly   109 GLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDME 173
            |....|                          |||..|.|:.|.
  Rat   279 GTGPGG--------------------------RRTGGGSGEAGA--------------------- 296

  Fly   174 ELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLP 238
                              ..||::|.|.|.:.|:.|.|.::||.:|||.|..|.||||||:||||
  Rat   297 ------------------PCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLP 343

  Fly   239 DKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTID 303
            |:||||:||||||||:|:|||||.| |:|.|:...:.|.|:::||||||:||.||:|.:.    :
  Rat   344 DRKKKFQTKVHRKTLNPIFNETFQF-SVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLD----N 403

  Fly   304 LAQTIEE------WRDLVSVEGEGGQEK--LGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGL 360
            |.:..|:      |||::    |||.||  ||::.|||.|:||||.|||.|::|.|||.||:.|.
  Rat   404 LLELAEQPPDRPLWRDIL----EGGSEKADLGELNFSLCYLPTAGLLTVTIIKASNLKAMDLTGF 464

  Fly   361 SDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEP 425
            ||||||.:::..|:||||:||||||.||||.|||:..|:|..|.::.:.|.:.|||||.||.:|.
  Rat   465 SDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEV 529

  Fly   426 IGRCILGCMGTGTELR-HWSDMLASPRRPIAQWHTLKDPEETDEILKNMK 474
            ||.|.:|........| ||::|||:||:|:..||.|.:.:......|..|
  Rat   530 IGVCRVGPEAADPHGREHWAEMLANPRKPVEHWHQLVEEKTLSSFTKGGK 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	14/91 (15%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	66/129 (51%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	72/135 (53%)
Syt3	NP_061995.1	Cysteine motif. /evidence=ECO:0000250\|UniProtKB:O35681	10..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..222		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..257		5/18 (28%)
		C2A_Synaptotagmin-1-5-6-9-10	297..422	CDD:176031	66/133 (50%)
		C2B_Synaptotagmin-3-5-6-9-10	431..565	CDD:176048	71/133 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820