DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Syt1

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001028852.2	Gene:	Syt1 / 25716	RGDID:	3803	Length:	421	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	250/417 - (59%)
Similarity:	302/417 - (72%)	Gaps:	8/417 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 AASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAE--RTGLPTWGVVAI-IIL 121
            :||...|.....|..||.....:|..|.|...|.:...::..:.:.|  :..||.|.::|| |:.
  Rat     3 SASHPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVA 67

  Fly   122 VFLVVFGIIFFCVRRFLKKRRTKDGK---GKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGD 183
            |.|||......|.:...||:..|.||   ||..::||.|:.||...|::...|.:..|...:..:
  Rat    68 VLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEE 132

  Fly   184 EEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKV 248
            :|:.:.|:|||:|.:.|:|||.:|.|.|.:|||.|||||||||||||||||:|||||||||||||
  Rat   133 KEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKV 197

  Fly   249 HRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRD 313
            |||||:|||||.|||| :||::...||||.|::|||||||||.|||.|||:.|:|.....|||||
  Rat   198 HRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRD 261

  Fly   314 LVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKK 378
            |.|.|.| .|||||||||||||||||||||||||||||||||||||||||||||.:|||||||||
  Rat   262 LQSAEKE-EQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKK 325

  Fly   379 KKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHW 443
            |||:|||.|||||||||||||||||||||:.:||||:|||:||.::.||:..:|...||.|||||
  Rat   326 KKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHW 390

  Fly   444 SDMLASPRRPIAQWHTLKDPEETDEIL 470
            |||||:|||||||||||:..||.|.:|
  Rat   391 SDMLANPRRPIAQWHTLQVEEEVDAML 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	22/78 (28%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	88/123 (72%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	112/134 (84%)
Syt1	NP_001028852.2	Syt1_N	5..112	CDD:409248	34/112 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..141		8/28 (29%)
		Phospholipid binding. /evidence=ECO:0000305	135..381		185/245 (76%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	86/121 (71%)
		C2B_Synaptotagmin-1	273..408	CDD:176047	109/134 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3592
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4122
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1456
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm45282
orthoMCL	1	0.900	-	-		OOG6_106413
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840