Protein Alignment Syt1 and Syt2

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_036797.2
• Gene: Syt2 / 24805
• RGDID: 3804
• Length: 422
• Species: Rattus norvegicus
• Alignment Length: 441
• Identity: 249/441 - (56%)
• Similarity: 307/441 - (69%)
• Gaps: 32/441 - (7%)

  Fly    43 REVDRQEQEVLAEKAAEAASQRIAQV----ESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEV 103
            |.:.::.||.:...|...|:..:|..    .||..:.|.|:||.....:    |.:...|:
  Rat     2 RNIFKRNQEPIVAPATTTATMPLAPAAPVDNSTESTGTGESQEDMFAKL----KDKFFNEI---- 58

  Fly   104 IAERTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEK 167
              .:..||.|.::|:.::..|::....| .|.:...||::.|..|||   .||:...:......:
  Rat    59 --NKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGK---GMKNAMNMKDMKGGQ 118

  Fly   168 VQPDMEE-LTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPY 231
            ...|.|. |||...||:||  :..:.||:|.|.|:|||.:|.|.|.|:||.||||||||||||||
  Rat   119 DDDDAETGLTEGEGEGEEE--KEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPY 181

  Fly   232 VKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVK 296
            |||:||||||||:|||||||||:|.|||||||| :||.:...||||.||:|||||||||.|||||
  Rat   182 VKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVK 245

  Fly   297 VPLCTIDLAQTIEEWRDLVSVEGEGGQ----EKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDV 357
            ||:.|:||.|.|||||||     :||:    |||||||.|||||||||||||.||||||||||||
  Rat   246 VPMNTVDLGQPIEEWRDL-----QGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDV 305

  Fly   358 GGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGT 422
            ||||||||||.:||||||||||||::||.|||||:|||||||:|||||||:.:||||:|||::|.
  Rat   306 GGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGK 370

  Fly   423 SEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEIL-KN 472
            :|.||:..:|...|||||||||||||:|||||||||:||..||.|.:| ||
  Rat   371 NEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKN 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	24/103 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	92/123 (75%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	107/134 (80%)
Syt2	NP_036797.2	Syt2_N	4..116	CDD:409249	28/124 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..43		7/26 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..141		13/43 (30%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		183/253 (72%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	92/127 (72%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	107/134 (80%)