DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Syt16

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001351210.1	Gene:	Syt16 / 238266	MGIID:	2673872	Length:	654	Species:	Mus musculus

Alignment Length:	323	Identity:	83/323 - (25%)
Similarity:	141/323 - (43%)	Gaps:	56/323 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 DEEDKQSEQ----------KLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLL 237
            :|:|..|.|          |.|.|:...||...:..|.||:::|:.||..|..|.:...|.:.||
Mouse   340 EEQDGTSLQVPHRLLEPISKCGDLDVIFEYRAVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLL 404

  Fly   238 PDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQI---------- 292
            |.||::.:|.:.|.. :|||.|..||..|...|..:..:.|.::...:.::...:
Mouse   405 PSKKQRGKTNIQRGP-NPVFKEKVTFTKLEPRDVASCAVRFRLYAARKMTRERMMGEKLFCLSHL 468

  Fly   293 ---GEVKVPLCTIDLAQTIEEWRDLVSVE--------------------GEGGQEKLGDICFSLR 334
               ||:||.|       .:|...:|.|.|                    ..||   :.::...|.
Mouse   469 HPEGEMKVTL-------VLEPRSNLSSGESPLSPSVVSHSDSASSTQSLSHGG---VPELLVGLS 523

  Fly   335 YVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQ-NGKRLKKKKTSIKKCTLNPYYNESFSF 398
            |..|.|:|:|.:::..:.:.:......|.|.|:.::. .|:.:.:.||||::...||.|.|:|.|
Mouse   524 YNATTGRLSVEMIKGSHFRNLAANRAPDTYGKLFLLNCVGQEMSRCKTSIRRGQPNPVYKETFVF 588

  Fly   399 EVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTG-TELRHWSDMLASPRRPIAQWHTL 460
            :|...|:..:.|::::.....:...|.||...||...:| .|..||.:|..|..:...:||||
Mouse   589 QVALFQLSDVTLMISIYSRRTMKRKEMIGWVALGQNSSGEEEQEHWEEMKESKGQQTCRWHTL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	37/136 (27%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	38/137 (28%)
Syt16	NP_001351210.1	C2A_Synaptotagmin-14_16	359..482	CDD:176035	35/130 (27%)
Syt16	NP_001351210.1	C2B_Synaptotagmin-14_16	515..652	CDD:176053	38/137 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910