Protein Alignment Syt1 and SYT11

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_016856248.1
• Gene: SYT11 / 23208
• HGNCID: 19239
• Length: 434
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 142/370 - (38%)
• Similarity: 212/370 - (57%)
• Gaps: 51/370 - (13%)

  Fly   135 RRFLKKRRTKDGKGKKG------VDMKSVQLL-----------GSA---------YKEKVQPDME 173
            ::.:|.||.|||.|::|      ||.....||           ||.         |.|:::..:.
Human    73 KKIIKVRRDKDGPGREGGRRNLLVDAAEAGLLSRDKDPRGPSSGSCIDQLPIKMDYGEELRSPIT 137

  Fly   174 ELT-----ENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALD---MGGTSDP 230
            .||     ..:....|||..    ||.|.|.::|:|...:|.||:.:|..||.:|   .|  |||
Human   138 SLTPGESKTTSPSSPEEDVM----LGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQG--SDP 196

  Fly   231 YVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEV 295
            |:|:.:||||:.:.:|:|.||||.|||:|||||..:||:...:..|.|.:..|||||:.|.||||
Human   197 YIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEV 261

  Fly   296 KVPLCTIDLAQ-TIEEWRDLVSVEGEGGQEKL--GDICFSLRYVPTAGKLTVVILEAKNLKKMDV 357
            .|||..:|.:. .::..||::.   ...|:.:  |::..||.|.|.|.::|||:|:|::|.|||:
Human   262 MVPLAGVDPSTGKVQLTRDIIK---RNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDI 323

  Fly   358 GGLS----DPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYD 418
            .|||    |||||:.:....||:.||||.:|||||||.:||||.:::|.:.:..|.:...|:|:|
Human   324 TGLSGRAPDPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFD 388

  Fly   419 RIGTSEPIGRCILGCMG-TGTELRHWSDMLASPRRPIAQWHTLKD 462
            |...:|.:||.|||... |.:...||.::..|||:|:|:||:|.:
Human   389 RTTKNEVVGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSLSE 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	12/42 (29%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	57/127 (45%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	62/141 (44%)
SYT11	XP_016856248.1	C2A_Synaptotagmin-4-11	158..283	CDD:176034	57/126 (45%)
		C2B_Synaptotagmin-4	292..432	CDD:176049	62/139 (45%)