DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and RPH3A

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001137326.1	Gene:	RPH3A / 22895	HGNCID:	17056	Length:	694	Species:	Homo sapiens

Alignment Length:	326	Identity:	110/326 - (33%)
Similarity:	163/326 - (50%)	Gaps:	30/326 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGG 226
            :|.::...|:.||     ||.:..|......||.|.|.|.||.:::||..|:|:|:.|..:|..|
Human   367 AAARQPPPPEEEE-----EEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNG 426

  Fly   227 TSDPYVKVYLLP--DKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKH 289
            .:|||||::|||  .|..|..||..|.|.:|::|||..:..:...|...|||..::.|.|:|..:
Human   427 LADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHN 491

  Fly   290 DQIGEVKVPL-------------C-----TIDLAQTIEEWRDLV-----SVEGEGGQEKLGDICF 331
            :.|||.:..|             |     .:..|.|....|.:.     .||..|..|:.|.|..
Human   492 EFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILV 556

  Fly   332 SLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESF 396
            ||.|....|.|.|.|:...:|..||..|.|||:||:.:..:..:..|.||.|||.||||.:||.|
Human   557 SLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEF 621

  Fly   397 SFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLK 461
            .:::....:.|..|.::|.|||...:::.||.|.||....|..|:||.:.|.:..:.|.:||.|:
Human   622 FYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQ 686

  Fly   462 D 462
            :
Human   687 N 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	48/148 (32%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	50/134 (37%)
RPH3A	NP_001137326.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		FYVE_RP3A	92..171	CDD:277301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..388		7/25 (28%)
		C2A_Rabphilin_Doc2	393..516	CDD:176000	44/122 (36%)
		C2B_Rabphilin_Doc2	553..685	CDD:176030	49/131 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910