Protein Alignment Syt1 and Syt12

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_620190.1
• Gene: Syt12 / 191595
• RGDID: 621876
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 454
• Identity: 115/454 - (25%)
• Similarity: 202/454 - (44%)
• Gaps: 92/454 - (20%)

  Fly    17 PAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQE 81
            |:|:..|..|...:.||..|.:                   .||..:|:         ....||.
  Rat    49 PSPSPFPNYDYRYLQQKYGEAY-------------------VEAKLKRV---------PPWNAQR 85

  Fly    82 STTTAVPVIK---KIEHVGEVVT-----EVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFL 138
            :||...|..|   .||...|.::     |::.....|..:|.                      |
  Rat    86 TTTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGT----------------------L 128

  Fly   139 KKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYD 203
            :|.::.|       .:.|:..:.:.:.:                       :..||::...::||
  Rat   129 RKSQSAD-------SLNSISSVSNTFGQ-----------------------DFTLGQVEVSMDYD 163

  Fly   204 FNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPY 268
            ..|::|.|.|:|.::|...:.......:::|.||||::....:::.|...|..|:|.|:....|.
  Rat   164 GASHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPT 228

  Fly   269 ADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDL-AQTIEEWRDLVSVEGEGGQEKLGDICFS 332
            | ...|:|.|::|..|...::...|.|::.|..:|| .|....|  |...:.....:.:|:|..|
  Rat   229 A-LEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGW--LYLQDQNKAADAVGEILLS 290

  Fly   333 LRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFS 397
            |.|:|||.:||||:::||||...:....:||:||:.::|:|:::.||||::|:...||.:||:..
  Rat   291 LSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMI 355

  Fly   398 FEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLK 461
            |.||...:|.:.|.|||.:....|..:.:|..|:|...:|....||:.|||:.|||::.||.::
  Rat   356 FSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGASGMGTTHWNQMLATLRRPVSMWHPVR 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	17/106 (16%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	35/124 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	54/134 (40%)
Syt12	NP_620190.1	C2	152..263	CDD:472691	30/111 (27%)
		C2B_Synaptotagmin-12	284..419	CDD:176051	54/134 (40%)