DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Y75B7AL.2

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_503404.3	Gene:	Y75B7AL.2 / 190697	WormBaseID:	WBGene00022285	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	49/221 - (22%)
Similarity:	80/221 - (36%)	Gaps:	63/221 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AADLESVDQK-------LE-ETHHSKFREVDR-------QEQEVLA---------EKAAEAASQR 64
            |.|||....|       :| ||....|..|:|       .|.|::.         |...:.||.|
Worm   272 AMDLEIQKAKAVVFEVLIELETESKVFATVERTAIGEMQSEYEIVLCSSHNVPFDEDFHKTASSR 336

  Fly    65 IAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGI 129
            |  :|..|.:..|...::...|.....||:...:.:::|:|   .|..:.::|  .||.:..:..
Worm   337 I--LERLTVTKKTNRLQTVFKATIFSSKIDRTIQTLSKVVA---CLIYFSILA--ALVGMYAYQN 394

  Fly   130 IFFCVRR------FLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDME------------ELT 176
            :...|.|      .:|.||..|   ...::|:...       |.:|.|..            |..
Worm   395 VELRVSRQNPFTPIVKYRRQAD---DVAIEMEEAM-------EDIQSDSTLEGDTQMLISSVETP 449

  Fly   177 ENAEEGDEEDKQSEQKLGRLNFKLEY 202
            |.|...|.||.::...    ||:|::
Worm   450 EIANSEDIEDLRNVNP----NFELDH 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	31/135 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	3/11 (27%)
		C2B_Synaptotagmin-1	326..461	CDD:176047
Y75B7AL.2	NP_503404.3	Amnionless	25..>268	CDD:291494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900