DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and snt-2

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_497261.2	Gene:	snt-2 / 185680	WormBaseID:	WBGene00004922	Length:	369	Species:	Caenorhabditis elegans

Alignment Length:	372	Identity:	160/372 - (43%)
Similarity:	231/372 - (62%)	Gaps:	25/372 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 WGVVAIIILVFLVVFGIIFFC--VRRFLKKRRTKDG--KGKKGVDM--KSVQLLGSAYKEKVQPD 171
            |...||   |...||.|:..|  :||.:.   |.:|  ...|.||:  .:|.:| |:....|||.
Worm     2 WATGAI---VCSPVFRILSTCCPIRRGVP---TSNGYHPRPKHVDIGNGAVPIL-SSKPITVQPT 59

  Fly   172 MEELTENAEEGDEEDKQSE---QKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVK 233
            ..:..|....|......|.   ::.|.::|::||||..:.|:||::.|.:|||:|..|.||||||
Worm    60 NSDYYEPVNNGTLPLSSSGALIKQYGNIHFRVEYDFEQSKLSVTIVSASDLPAMDRNGMSDPYVK 124

  Fly   234 VYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVP 298
            ||:||::|:||||::.|.||:|.:||||.| |:|:.:..:|||:..::|:||.||.|::|::.||
Worm   125 VYVLPERKQKFETRIIRNTLNPTYNETFQF-SIPFNELHSKTLMLVVYDYDRLSKDDKMGQLSVP 188

  Fly   299 LCTIDLAQTIEEWRDLVSVEGEGGQE-KLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSD 362
            |.:||...|.:..|.|...|.:..:| :|||||||.||.|..|.:|:.|:||:|||||||||.||
Worm   189 LESIDFGITTDIERPLQKPEKDDEKECRLGDICFSTRYRPATGTVTLTIMEARNLKKMDVGGSSD 253

  Fly   363 PYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIG 427
            |||||.:....|.|.|||||.|..||||||||||.|::....|:|:.|:|:|.|||::..::.||
Worm   254 PYVKIYLHHGRKLLSKKKTSRKYKTLNPYYNESFQFKIEPHMIEKVHLIVSVWDYDKMSKNDFIG 318

  Fly   428 RCILGCMGTG-TELRH-----WSDMLASPRRPIAQWHTLKDPEETDE 468
            ...||..... .::.|     |::|:.| |||:.|||||::..|.::
Worm   319 EVTLGSKHLNLPQITHACSEQWAEMMTS-RRPVVQWHTLQERMEKEK 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	8/24 (33%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	59/123 (48%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	73/140 (52%)
snt-2	NP_497261.2	C2	85..206	CDD:301316	59/121 (49%)
snt-2	NP_497261.2	C2B_Synaptotagmin-1	217..357	CDD:176047	73/140 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880