DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and sue-1

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_492083.2	Gene:	sue-1 / 184108	WormBaseID:	WBGene00006306	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	116/551 - (21%)
Similarity:	182/551 - (33%)	Gaps:	157/551 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PNAKSETDAKPEAEPAPASEPAADLESV----------------------DQKLEETHHSKFREV 45
            |:|....:.:|.....| ..|.|:|.::                      |...:|...  :.|.
Worm    54 PSAAPHLERRPSGRQLP-RPPTAELSNLTSLAHNGPGNSQCSLSPVSLTPDPTPDEPEF--YEEE 115

  Fly    46 DRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGL 110
            |..|.||:.|..|:      .:.|........|.::......|     |.:..:..|::......
Worm   116 DVDESEVVEEDYAQ------EEEEEGDDGEVVEYEDPVVVTPP-----EEIRRISPEILIAPPPQ 169

  Fly   111 PTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQ------ 169
            |                       ||.          .|..|...|::.:.|......:
Worm   170 P-----------------------RRM----------SKFSVHSPSIEQITSKSSSDTEDPIAHG 201

  Fly   170 -------PDMEELTEN---------AEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEE 218
                   |:...:.||         .........|..:.||.|:..|.|......|.|||.:.|.
Worm   202 LDPSLYSPNAPIIIENNNTAIHKTSVASSSSPTPQQPRGLGLLHCSLLYFAVRKRLRVTVTKIEA 266

  Fly   219 LPALDMGGTSDPYVKVYLL---------PDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNK 274
            |     .|...|.::::.|         ..|::..|||..|   .|:||..|.|.::.:.:...|
Worm   267 L-----AGELKPEMEIHALCKVSIPGLKGGKEQTSETKRGR---DPLFNHEFFFDNVTHEELDTK 323

  Fly   275 TLVFAIFDFDRFSKHDQ--IGEVKVPLCTIDLAQT------IEEWRDLVSVEGEGGQEKLGDICF 331
            .::..........|..:  |||..|||..|....|      |||.:.||       .:|||.|..
Worm   324 VVIITACHAGGGIKGKEIVIGEASVPLRDIREMNTKKEIKFIEEIKGLV-------PKKLGKIYT 381

  Fly   332 SLRYVPTAGKLTVVILEAKNLKKMD------VGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNP 390
            |......:.:||:      ||||:|      :.|..|..|||.:.| |.:.:.|.:.:.|.|.:.
Worm   382 SSIIEKDSKRLTI------NLKKVDALPKCGLIGAPDVCVKITLTQ-GAKTQTKSSRVIKNTCSA 439

  Fly   391 YYNESFSF--EVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGC--MGTG----TELRHWSDML 447
            .|||:..|  ......:.:..:|::|.|..|..|    |...:||  :|.|    :|:..|....
Worm   440 VYNEAVMFLCGTSKNDLAQTSIVISVHDAQRTCT----GDDTIGCAYLGIGAVDKSEIDQWKGTT 500

  Fly   448 ASPRRPIAQWHTLKDP---------EETDEI 469
            ....:.....||||.|         |..|::
Worm   501 EHLGKEYKGNHTLKAPITAPPVHVAEANDDV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	21/152 (14%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	38/140 (27%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	39/148 (26%)
sue-1	NP_492083.2	C2	242..349	CDD:301316	28/114 (25%)
sue-1	NP_492083.2	C2	389..513	CDD:301316	34/134 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010