DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and snt-7

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_510526.2	Gene:	snt-7 / 181615	WormBaseID:	WBGene00011682	Length:	416	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	85/349 - (24%)
Similarity:	160/349 - (45%)	Gaps:	60/349 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KGVDMKSVQLLGSAYKEKVQPDMEELTENAEE--------GDEE--DKQSEQKLGRLNFKLEYDF 204
            || |:.|:.::..| |:..:.....|.:|..:        |||.  ...:...:|.:...:.:|.
Worm    93 KG-DLTSLFMIPKA-KKGARSMFSNLHQNQFDRGLYQFPTGDESACSSVTMSAVGSIQLSVSHDV 155

  Fly   205 NSNSLAVTVIQAEELPALDMGGTSDPYVKVYL-LPDKKK---KFETKVHRKTLSPVFNETFTFKS 265
            |.|.|.||:::|.:||........:|::||.| :||.||   ..:||.:..|.||:.||.|.| |
Worm   156 NLNLLTVTIVKAVDLPTKREDDLPNPFMKVSLEIPDSKKPNVDHQTKTYNGTASPLINEDFYF-S 219

  Fly   266 LPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEE---------WRDLVSVEGEG 321
            :.........|...::|:|:||..:.:|     .|.:.|.:..|.         |.:::..| :|
Worm   220 VTSQQVSICRLEVMVYDYDQFSVDECVG-----YCWLTLGRINEHFEHDLPTLFWAEVLPYE-DG 278

  Fly   322 GQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQ-NGKRLKKKKTSIKK 385
            ..:..|.:.|:|.|:..|.:||:.|.:.:|::..:.|.::   :::.::. ..|.|||||||:||
Worm   279 ENKGYGQVLFALSYLSHAQRLTMNIFKVRNVRFRNGGNVA---LRVTLLDGEEKPLKKKKTSLKK 340

  Fly   386 CTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGT-----------SEPIGRCILGCMGTGTE 439
            ...:..:||..:|.:|...:.::.:.|.::  ...||           ..|:.:|        .:
Worm   341 AARSVQFNECLTFSIPKHTLCEVFITVELI--TETGTFGIASRTLSRMQLPLHKC--------KD 395

  Fly   440 LRHWSDMLASPRRPIAQWHTLKDP 463
            |  |..::...:.. |:|:..:.|
Worm   396 L--WRAIIREEKSQ-ARWYPFEQP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	38/136 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	33/146 (23%)
snt-7	NP_510526.2	C2	145..257	CDD:387358	36/117 (31%)
snt-7	NP_510526.2	C2	283..>374	CDD:387358	25/95 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810