Protein Alignment Syt1 and rbf-1

DIOPT Version :9

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001367825.1
• Gene: rbf-1 / 175943
• WormBaseID: WBGene00004316
• Length: 1123
• Species: Caenorhabditis elegans
• Alignment Length: 587
• Identity: 135/587 - (22%)
• Similarity: 205/587 - (34%)
• Gaps: 156/587 - (26%)

  Fly     8 ETDAKPEAEPAPASE----------------------PAADLESVDQKLEETHHSKFRE------ 44
            :.|:.||:.|:..|.                      |.||..|:|..:.::.||..::
 Worm   557 DDDSSPESRPSTRSTSPRHSLATPSSYAHDTCHDTSLPDADTRSIDSGVVQSDHSNPQQSGLTCS 621

  Fly    45 ----VDRQEQEVLAEKAAEAASQRIAQVESTT-RSATTEAQESTTTAVPVIKK------------ 92
                ...|:|......:.....:||:..:.|| |.|.:.:..|..|..|.|..
 Worm   622 SSSLTPLQQQASHDHHSGGGTPRRISNPDRTTSRVAQSASGTSLVTPPPPISSRTSPDNCNSSPL 686

  Fly    93 --IEH---------------VGEV------------------VTEVIAERTGLPTWGVVAIIILV 122
              :||               ||..                  :.:.:..:|......:.|
 Worm   687 NVMEHKSSSASTASSGGNRRVGSAEPVLNNHHAMHNNQNHNDINKKLISQTSRAESPLAA----- 746

  Fly   123 FLVVFGIIFFCVRRFL--------KKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDM------- 172
                       ...||        :|.|.:||.|:    :.|:||..|.  :.|.|.:
 Worm   747 -----------SSSFLSSPDDDTKQKNRRRDGVGR----VNSLQLRTSL--DDVAPPVAPISKMN 794

  Fly   173 ------------------------------EELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSN 207
                                          ||..|.|.....|.......||.:...|.|.....
 Worm   795 GHIVSSEPTSSTTSNQNHTSVPIPTVPVVPEEEEEKAITASTESASEPGSLGSITLTLTYHSADK 859

  Fly   208 SLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYAD 270
            .|.:.:|:|:.|.|:|..|.||||||.:|||...|  |..:|...|||:|.:||..::..:...|
 Worm   860 KLKMHLIRAKNLKAMDSNGFSDPYVKFHLLPGNTKATKLTSKTIEKTLNPEWNEEMSYYGITEDD 924

  Fly   271 AMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQT------IEEWRDLVSVEGEGGQEKLGDI 329
            ...|.|...:.|.||... |.:||.::.|..::..:.      :|....:.....|...|..|.|
 Worm   925 KEKKILRVTVLDRDRIGS-DFLGETRIALKKLNDNEMKKFNLYLESALPVPQQTKEEENEDRGKI 988

  Fly   330 CFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNE 394
            ...|:|....|.|.:.|.....|..||..|.||||.|:::.....:..:.|||.||.||||.:||
 Worm   989 NVGLQYNIQQGSLFININRCVELVGMDSTGFSDPYCKVSLTPITSKAHRAKTSTKKRTLNPEWNE 1053

  Fly   395 SFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHT 459
            ...|.|||:.:.|..|.:.|.|:|.....:.||..:|.........|.|...:.:|...:..||.
 Worm  1054 QLQFVVPFKDLPKKTLQIGVYDHDLGKHDDYIGGILLSTSAKDERGRQWIKCIENPGTLVEAWHR 1118

  Fly   460 LK 461
            |:
 Worm  1119 LE 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	30/207 (14%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	40/131 (31%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	44/134 (33%)
rbf-1	NP_001367825.1	FYVE_2	220..342	CDD:396754
		C2A_Rabphilin_Doc2	845..967	CDD:176000	39/122 (32%)
		C2B_Rabphilin_Doc2	987..1119	CDD:176030	43/131 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910