DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Rph3a

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_598202.2	Gene:	Rph3a / 171039	RGDID:	620073	Length:	684	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	109/319 - (34%)
Similarity:	158/319 - (49%)	Gaps:	27/319 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 QPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVK 233
            ||...|  |..||.:..|......||.|.|.|.||.::::|..|:|:|:.|..:|..|.:|||||
  Rat   361 QPPPAE--EEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVK 423

  Fly   234 VYLLP--DKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVK 296
            ::|||  .|..|..||..|.|.:||:|||..:..:...|...|||..::.|.|:|..::.|||.:
  Rat   424 LHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETR 488

  Fly   297 VPLCTIDLAQ------------------TIEEWRDLVSVEGE-----GGQEKLGDICFSLRYVPT 338
            ..|..:...|                  |....|.:...|.|     |..|:.|.|..||.|...
  Rat   489 FSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQ 553

  Fly   339 AGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFE 403
            .|.|.|.|:...:|..||..|.|||:||:.:..:..:..|.||.|||.||||.:||.|.:::...
  Rat   554 QGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHS 618

  Fly   404 QIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKD 462
            .:.|..|.::|.|||...:::.||.|.||....|..|:||.:.|.:..:.|.:||.|::
  Rat   619 DLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQN 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	47/143 (33%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	50/134 (37%)
Rph3a	NP_598202.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		FYVE_RP3A	88..168	CDD:277301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..377		6/17 (35%)
		PRK07764	<175..352	CDD:236090
		C2A_Rabphilin_Doc2	383..506	CDD:176000	45/122 (37%)
		C2B_Rabphilin_Doc2	543..675	CDD:176030	49/131 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910