Protein Alignment Syt1 and Sytl4

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_536335.2
• Gene: Sytl4 / 140594
• RGDID: 620204
• Length: 672
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 129/521 - (24%)
• Similarity: 224/521 - (42%)
• Gaps: 96/521 - (18%)

  Fly    22 EPAAD-LESVDQK-LEETHHS------KFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTE 78
            :||.: .|:|.|. |::|...      :..:..::||.||.|.....:.:...:.||.:..:.|.
  Rat   143 KPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTA 207

  Fly    79 AQESTTT--------AVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVR 135
            ..:||:.        ..|..||:......|.:.||........|....:|.             :
  Rat   208 DSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIF-------------K 259

  Fly   136 RFLKKRRTKDGKGKKGVDMKSVQ------LLGSAYKE--KVQPDMEELTENAEEGDEEDKQSEQK 192
            :..:|........|..:|::...      :||...|.  .:..||||..|..|:.|...|...||
  Rat   260 KNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQK 324

  Fly   193 L---------------------------------GRLNFKLEYDFNSNSLAVTVIQAEELPALDM 224
            |                                 |::.|.|:::..:.:|.:.|.:..:|...|.
  Rat   325 LARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADE 389

  Fly   225 G-GTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRF 286
            . ..|:||||.||||||.:  |.:|.:.|.|::|:::|||.:: :..:....:||.|:::...||
  Rat   390 AKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYE-ISESLLAQRTLQFSVWHHGRF 453

  Fly   287 SKHDQIGEVKVPLCTIDLAQTIEEWRDL---VSVEGEGG-QEKLGDICFSLRYVPTA-------- 339
            .::..:||.:|.:.:..|.:.::....|   :|.|...| ....|::..||:|:|.:
  Rat   454 GRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDR 518

  Fly   340 --------GKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESF 396
                    |:|.|.|.|||||.....||.||.:||..::....:..|:||.:.|.||||:||.:|
  Rat   519 KKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTF 583

  Fly   397 SFE-VPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            .:. |..|.:|.:||.:||.|.:.:.:::.:|...|| :|||.......|.:.|....::.|..:
  Rat   584 VYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG-VGTGISSGEVVDWMDSTGEEVSLWQKM 647

  Fly   461 K 461
            :
  Rat   648 R 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	16/112 (14%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	38/162 (23%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	48/151 (32%)
Sytl4	NP_536335.2	PHD_SF	8..121	CDD:473978
		FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..222		4/22 (18%)
		C2A_SLP-4_5	358..482	CDD:175995	35/124 (28%)
		C2B_SLP_1-2-3-4	497..662	CDD:175987	48/153 (31%)