DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and Sytl4

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_536335.1	Gene:	Sytl4 / 140594	RGDID:	620204	Length:	672	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	128/521 - (24%)
Similarity:	224/521 - (42%)	Gaps:	96/521 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EPAAD-LESVDQK-LEETHHS------KFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTE 78
            :||.: .|:|.|. |::|...      :..:..::||.||.|.....:.:...:.||.:..:.|.
  Rat   143 KPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTA 207

  Fly    79 AQESTTT--------AVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVR 135
            ..:||:.        ..|..||:......|.:.||........|....:|.             :
  Rat   208 DSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIF-------------K 259

  Fly   136 RFLKKRRTKDGKGKKGVDMKSVQ------LLGSAYKE--KVQPDMEELTENAEEGDEEDKQSEQK 192
            :..:|........|..:|::...      :||...|.  .:..|||:..|..|:.|...|...||
  Rat   260 KNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEDEEEEEEDIDHLVKLHRQK 324

  Fly   193 L---------------------------------GRLNFKLEYDFNSNSLAVTVIQAEELPALDM 224
            |                                 |::.|.|:::..:.:|.:.|.:..:|...|.
  Rat   325 LARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADE 389

  Fly   225 G-GTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRF 286
            . ..|:||||.||||||.:  |.:|.:.|.|::|:::|||.:: :..:....:||.|:::...||
  Rat   390 AKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYE-ISESLLAQRTLQFSVWHHGRF 453

  Fly   287 SKHDQIGEVKVPLCTIDLAQTIEEWRDL---VSVEGEGG-QEKLGDICFSLRYVPTA-------- 339
            .::..:||.:|.:.:..|.:.::....|   :|.|...| ....|::..||:|:|.:
  Rat   454 GRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDR 518

  Fly   340 --------GKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESF 396
                    |:|.|.|.|||||.....||.||.:||..::....:..|:||.:.|.||||:||.:|
  Rat   519 KKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTF 583

  Fly   397 SFE-VPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            .:. |..|.:|.:||.:||.|.:.:.:::.:|...|| :|||.......|.:.|....::.|..:
  Rat   584 VYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLG-VGTGISSGEVVDWMDSTGEEVSLWQKM 647

  Fly   461 K 461
            :
  Rat   648 R 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	25/129 (19%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	38/162 (23%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	48/151 (32%)
Sytl4	NP_536335.1	FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222		4/22 (18%)
		C2A_SLP-4_5	358..482	CDD:175995	35/124 (28%)
		C2B_SLP_1-2-3-4	497..662	CDD:175987	48/153 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810