DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and SYT2

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_016855798.1	Gene:	SYT2 / 127833	HGNCID:	11510	Length:	479	Species:	Homo sapiens

Alignment Length:	470	Identity:	258/470 - (54%)
Similarity:	318/470 - (67%)	Gaps:	50/470 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRS-ATTEAQ 80
            |...|.||..            .:..|.:.::.||.:...|...|:..|..|:::|.| ...|:|
Human    45 PLHLSSPAVS------------SATMRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQ 97

  Fly    81 ESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTK 144
            |.      :..|::.  ::..|:  .:..||.|.::||.::..|::....| .|.:...||::.|
Human    98 ED------MFAKLKE--KLFNEI--NKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNK 152

  Fly   145 --DGKGKKGV----DMKSVQLLGSAYKEKVQPDMEE-LTENAEEGDEEDKQSEQKLGRLNFKLEY 202
              .|||.|..    |||..||      .:...|.|. |||...||:||  :..:.||:|.|.|:|
Human   153 KEKGKGMKNAMNMKDMKGGQL------PQDDDDAETGLTEGEGEGEEE--KEPENLGKLQFSLDY 209

  Fly   203 DFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLP 267
            ||.:|.|.|.|:||.|||||||||||||||||:||||||||:|||||||||:|.|||||||| :|
Human   210 DFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK-VP 273

  Fly   268 YADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQ----EKLGD 328
            |.:...||||.||:|||||||||.|||||||:.|:||.|.|||||||     :||:    |||||
Human   274 YQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDL-----QGGEKEEPEKLGD 333

  Fly   329 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYN 393
            ||.|||||||||||||.||||||||||||||||||||||.:||||||||||||::||.|||||:|
Human   334 ICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFN 398

  Fly   394 ESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWH 458
            ||||||:|||||||:.:||||:|||::|.:|.||:..:|...|||||||||||||:|||||||||
Human   399 ESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWH 463

  Fly   459 TLKDPEETDEIL-KN 472
            :||..||.|.:| ||
Human   464 SLKPEEEVDALLGKN 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	26/120 (22%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	92/123 (75%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	107/134 (80%)
SYT2	XP_016855798.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3696
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1535
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm41141
orthoMCL	1	0.900	-	-		OOG6_106413
Panther	1	1.100	-	-	LDO	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4219
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870