DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and Syt17

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_006507265.3	Gene:	Syt17 / 110058	MGIID:	104966	Length:	517	Species:	Mus musculus

Alignment Length:	349	Identity:	133/349 - (38%)
Similarity:	203/349 - (58%)	Gaps:	35/349 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VDMKSVQL-LGSAYKEKVQPD------------------MEELTENAEEGD---EEDKQSEQKLG 194
            :|:|.|:. :.||.||.:||.                  :..|..|.::.|   :|:..|:.:||
Mouse   165 IDIKPVEFGVLSAKKESIQPSVLRRTYTPDDYFRKFEPRLYSLDSNLDDVDSLTDEEIMSKYQLG 229

  Fly   195 RLNFKLEYDFNSNSLAVTVIQAEELP--------ALDMGGTSDPYVKVYLLPDKKKKFETKVHRK 251
            .|:|..:||...|.|.|.||:|.:||        ..|| ..|:||||:.||||:|...:|.|.||
Mouse   230 MLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDM-AHSNPYVKICLLPDQKNSKQTGVKRK 293

  Fly   252 TLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVS 316
            |..|||.|.:||: :|:.:|..:||:..:.|||:||:|..||:|.||||.:||.:....|:.|
Mouse   294 TQKPVFEERYTFE-IPFLEAQRRTLLLTVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKAL-- 355

  Fly   317 VEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKT 381
            :.....:.:||::..||.|:|:||:|.|.|:.||.|.:.||...|||:|||.::...|.:|.|||
Mouse   356 IPSSQNEVELGELLLSLNYLPSAGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKT 420

  Fly   382 SIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTG-TELRHWSD 445
            |..:.|::|:|||||||:||.|:::...||.||..::...:::.|||.::|...:| :|..||..
Mouse   421 SFLRGTIDPFYNESFSFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSESNHWRR 485

  Fly   446 MLASPRRPIAQWHTLKDPEETDEI 469
            ||.:.|..:.|||:|:...|.|.:
Mouse   486 MLNTHRTAVEQWHSLRSRAECDRV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	58/131 (44%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	58/135 (43%)
Syt17	XP_006507265.3	C2A_Synaptotagmin-15-17	229..357	CDD:176036	57/131 (44%)
Syt17	XP_006507265.3	C2B_Synaptotagmin-17	366..500	CDD:176055	57/133 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820