DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt11

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_031747300.1	Gene:	syt11 / 101731321	XenbaseID:	XB-GENE-13579723	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	323	Identity:	124/323 - (38%)
Similarity:	198/323 - (61%)	Gaps:	8/323 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 KGKKGVDMKSV--QL-LGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNS 208
            ||..|:...:.  || :.|:|.::..|.....:..::........::..||.|:..::|:|...:
Frog   108 KGPNGLATATCTDQLPVHSSYGDEFSPGQSLTSSGSKSSSPSSPDADTTLGTLSLSVDYNFPKKA 172

  Fly   209 LAVTVIQAEELPALD-MGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAM 272
            |.||:.:|..||.:| ....|||::|:.:|||||.:.:|:|.||||.|||:|||||..:||:...
Frog   173 LVVTIQEAHGLPVMDEHSQCSDPFIKMTILPDKKHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQ 237

  Fly   273 NKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQ-TIEEWRDLVSVEGEGGQEKLGDICFSLRYV 336
            :..|.|.:..|||||:.|.||||.|||..:|.:. .::..||::....:....: |::..||.|.
Frog   238 DLVLHFLVLSFDRFSRDDVIGEVLVPLAGVDPSTGKVQITRDIIKRNFQKCMSR-GELQVSLSYH 301

  Fly   337 PTAGKLTVVILEAKNLKKMDVGGLS-DPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEV 400
            |.|.::|||:|:||:|.:||:.||| :||||:.:..:.||:.||||.:|||||||.:||||.:::
Frog   302 PVAQRMTVVVLKAKHLPRMDITGLSGNPYVKVNVYYSRKRIAKKKTHVKKCTLNPVFNESFIYDI 366

  Fly   401 PFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMG-TGTELRHWSDMLASPRRPIAQWHTLKD 462
            |.:.:..|.:...|:|:||...::.|||.|||... |...:.||.::..:||:|:|:||.|.:
Frog   367 PTDLLPDISIEFLVIDFDRTVKNQVIGRVILGAHSVTANGVEHWREVCENPRKPVAKWHCLSE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	55/125 (44%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	60/136 (44%)
syt11	XP_031747300.1	C2A_Synaptotagmin-4-11	156..282	CDD:176034	55/125 (44%)
syt11	XP_031747300.1	C2B_Synaptotagmin-4	291..428	CDD:176049	60/137 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920