DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and LOC100497338

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_002938753.2	Gene:	LOC100497338 / 100497338	-ID:	-	Length:	398	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	110/390 - (28%)
Similarity:	192/390 - (49%)	Gaps:	60/390 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 VVAIIILVFLVVFGIIFFCVRRFLK-----KRRTK---DG-----KGKKGVDMKSV-----QLLG 161
            ::.:.|.:|||...::.:.:.::|:     .|..|   ||     |....:.:|||     ::..
Frog    23 LLGVAIFLFLVAIFLLVYNLYKYLRYKSSVARNEKTYLDGTYVEKKTTSNILLKSVAPTFLEITR 87

  Fly   162 SAYKEKVQ---PDMEELTE-------NAEEGDEEDKQSE-QKLGRLNFKLEYDFNSNSLAVTVIQ 215
            .....|:|   .:||:|.|       :.|..|:.|.... ...|:|...|.||....:|.:.||:
Frog    88 KEQDSKIQLMRKEMEKLEERLTPSPPSTESLDDLDSNPPLMPRGKLKLSLYYDKKKMALLINVIE 152

  Fly   216 AEELPALDMGGTSDPYV--KVYLLPDKK--------KKFETKVHRKTLSPVFNETFTFKSLPYAD 270
            |.:|||    .:.||:|  ||:...|..        .:::|||.:.:.:|||.|:||. :|..:.
Frog   153 ATDLPA----HSHDPFVRIKVFSKADDPHSSVQTIIHEWDTKVVKNSRNPVFVESFTC-TLKESQ 212

  Fly   271 AMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEK----LGDICF 331
            .::.:|.|.:.|||::|:|..|||.:..|..:..::|:|.:.||        |||    :|::..
Frog   213 LLSTSLKFEVKDFDKYSRHTLIGETRATLQGLKTSKTLELYEDL--------QEKTKDAIGEVLI 269

  Fly   332 SLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESF 396
            ||:.:|||.|:.|.||:.|. ..:......|.|.:|.:..|..:.|.:|:|::..:....:||:|
Frog   270 SLKCLPTAQKIEVGILKFKT-SSLSTISERDVYARIDVFTNQHKQKHQKSSLRAKSKVTVFNETF 333

  Fly   397 SFEVPFEQIQKICLVVTVVDYDRIGTSEP-IGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            .|.:| :..:..||::..: |:.|.:... ||:..||...|..|..||..|:.:.|:|:|:||.|
Frog   334 LFGLP-DPGKTHCLILVSL-YETIASGRKLIGQTSLGNQNTKAEDGHWELMMQTLRQPVAKWHPL 396

Fly 461 460
Frog 397 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	4/20 (20%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	43/133 (32%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	42/136 (31%)
LOC100497338	XP_002938753.2	C2	129..258	CDD:417471	43/141 (30%)
LOC100497338	XP_002938753.2	C2	265..396	CDD:417471	41/133 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910