DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and sytl5

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_012813070.1	Gene:	sytl5 / 100496000	XenbaseID:	XB-GENE-982310	Length:	814	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	116/539 - (21%)
Similarity:	204/539 - (37%)	Gaps:	123/539 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEV------LAEKAAE 59
            |...|..:.|.:.|:.|..:......::|:|..:.............|...:      .|.:::.
Frog   265 MISQASFKVDVRSESRPGSSLSARGSVDSLDTGVSSPKSKGNAPSSYQSSSINVIGTLPARQSSP 329

  Fly    60 AASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFL 124
            .||...|...|.:||......: |::::|......|          ||....|..:|
Frog   330 TASMHSAASNSHSRSGVQNGTK-TSSSIPEDMSKGH----------ERRASATPSLV-------- 375

  Fly   125 VVFGIIFFCVRRFLKKRRTKD---------GKGKKGVDMKSVQL-----LGSAYKEKVQPDMEEL 175
                    ..|..|...::|.         .:.::.:.|:|:.:     ....|.:|:..|.::|
Frog   376 --------ISRASLSSEQSKSEYDLSGHFTEENQESISMRSISVPDYLNKDPEYIDKIDEDFDDL 432

  Fly   176 --TENAEEGDEEDKQSEQKLGRLN---------------------------------FKLEYDFN 205
              :.|..:.......|::|...||                                 ..:.|.:.
Frog   433 GPSTNLTKSMNAHTLSDRKWTHLNVPDADADTRSLTSISLYSETGDYGNLRITGEILLNINYSYK 497

  Fly   206 SNSLAVTVIQAEELPALD-MGGTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLP 267
            :.:|.|.|.....|...| ....:|||||.||||||.:  |.:||:...|..|.||||..: .:.
Frog   498 TGALNVVVKNCRNLAVADEKKNRTDPYVKAYLLPDKSRQSKRKTKIKTNTTDPDFNETLKY-VIS 561

  Fly   268 YADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDL---VSVEGEGGQEKLGDI 329
            :.....:||...::..|||.::..:|||.:||.:.:.....:|...|   :.:..:...:..|:|
Frog   562 HTQLETRTLQLTVWHNDRFGRNSFLGEVDIPLDSCNFENQEDECFQLQPKMDLASDVTLQYKGEI 626

  Fly   330 CFSLRY-----------------------------VPTAGKLTVVILEAKNLKKMDVGGLSDPYV 365
            ...|||                             ||:.|.:.|:|..||||..|..||.||.:|
Frog   627 TVGLRYITPEKNLTLPLDKVAEKKSFRKSKKANVKVPSGGLVEVLIKNAKNLTAMKSGGSSDTFV 691

  Fly   366 KIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSF-EVPFEQIQKICLVVTVVDYDRIGTSEPIGRC 429
            |..::.:..:..|.||.:.|.|:||.:|.:|:| .:....:..:|:.:||...:.:.::..:|..
Frog   692 KGYLLPDNNKSTKHKTPVVKKTVNPEWNHTFTFASLQTSDLSNVCVELTVWGKESLTSNVFLGGV 756

  Fly   430 ILGCMGTGT---ELRHWSD 445
            .||| |:|.   ::..|.|
Frog   757 CLGC-GSGVSYGDIVDWMD 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	21/136 (15%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	41/162 (25%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	42/153 (27%)
sytl5	XP_012813070.1	FYVE_Slp5	65..111	CDD:277305
		C2A_SLP-4_5	485..609	CDD:175995	37/124 (30%)
		C2B_SLP_1-2-3-4	623..801	CDD:175987	42/153 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910